INT226421

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.70
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il33) extracellular region (Il33) nucleus (Il33)
Anatomy Link Frequency
skin 1
mast cell 1
Il33 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 142 99.54 Very High Very High Very High
Inflammatory response 21 96.24 Very High Very High Very High
Inflammation 183 87.60 High High
Inflammatory stimuli 3 23.60 Low Low
antagonist 37 5.00 Very Low Very Low Very Low
chemokine 26 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 321 99.88 Very High Very High Very High
Sprains And Strains 10 99.80 Very High Very High Very High
Anaphylaxis 68 99.36 Very High Very High Very High
INFLAMMATION 208 96.24 Very High Very High Very High
Targeted Disruption 20 91.56 High High
Eczema 4 63.52 Quite High
Rhinitis 14 59.44 Quite High
Necrosis 4 54.84 Quite High
Pruritus 1 52.36 Quite High
Retinoblastoma 1 41.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, we have observed differences in the baseline levels of IL-33 within the skin of the different strains of mice studied and yet the changes in the levels of IL-33 induced during anaphylaxis were relatively similar.
Regulation (changes) of IL-33 in skin associated with anaphylaxis and sprains and strains
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.76 Pain Relevance 0.14
That different stimuli, which drive similar expression of other cytokines, exhibit differential effects on IL-33 suggests that IL-33 might be an important determinate of the composition and strength of the inflammatory response.
Regulation (effects) of IL-33 associated with inflammatory response and cytokine
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.25 Pain Relevance 0.21
This might suggest strain-specific influences on homeostatic IL-33 levels in cells such as endothelium that do not impact mast cell-derived IL-33.
Regulation (influences) of homeostatic IL-33 in mast cell associated with sprains and strains
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.85 Pain Relevance 0.14
IL-33 modulation and asthma
Regulation (modulation) of IL-33 associated with asthma
4) Confidence 0.05 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.84 Pain Relevance 0.19

General Comments

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