INT226434

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.87
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR3) extracellular space (CCR3) cell adhesion (CCR3)
plasma membrane (CCR3) signal transducer activity (CCR3)
Anatomy Link Frequency
eosinophils 3
sputum 1
lung 1
CCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 86 100.00 Very High Very High Very High
antagonist 72 100.00 Very High Very High Very High
Inflammation 244 97.60 Very High Very High Very High
cytokine 243 79.44 Quite High
Central nervous system 63 32.52 Quite Low
adenocard 5 23.28 Low Low
agonist 49 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 682 99.12 Very High Very High Very High
INFLAMMATION 256 97.60 Very High Very High Very High
Hookworm Infection 74 96.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 330 85.16 High High
Targeted Disruption 46 84.40 Quite High
Adhesions 45 79.00 Quite High
Hypersensitivity 46 78.44 Quite High
Infection 164 75.68 Quite High
Toxicity 8 73.72 Quite High
Viral Meningitis 54 66.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we have demonstrated that activated eosinophils express relatively higher levels of the eotaxin receptor (CCR3), suggesting that these cells may be recruited to sites of inflammation.
Positive_regulation (levels) of CCR3 in eosinophils associated with inflammation
1) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.54 Pain Relevance 0.05
Moreover, we have demonstrated that activated eosinophils express relatively higher levels of the eotaxin receptor (CCR3), suggesting that these cells may be recruited to sites of inflammation.
Positive_regulation (levels) of eotaxin receptor in eosinophils associated with inflammation
2) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.54 Pain Relevance 0.05
The allergen-induced levels of beta-chain mRNA and CCR3 mRNA in sputum-derived cells were inhibited by TPIASM8, but no significant effects on cell surface protein expression of CCR3 and the beta-chain were found.
Positive_regulation (induced) of CCR3 in sputum
3) Confidence 0.32 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.74 Pain Relevance 0.04
N-nonanoyl (NNY)-CCL14[10-74] (NNY-CCL14) is an N-terminally truncated and modified peptide derived from the chemokine CCL14 that in vitro inhibits the activity of CCR3 on human eosinophils, because it is able to induce internalization of CCR3 and to desensitize CCR3-mediated intracellular calcium release and chemotaxis.
Positive_regulation (induce) of CCR3 in eosinophils associated with chemokine
4) Confidence 0.22 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.28 Pain Relevance 0.14
CCR3, CCR4, CCR8, and CRTH2 non-peptide antagonists are involved in the recruitment and/or activation of Th2 cells in the lung and are now being evaluated for the treatment of bronchial asthma but so far, no clinical data for these compounds have been reported.
Positive_regulation (evaluated) of CCR3 in lung associated with asthma and antagonist
5) Confidence 0.22 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.44 Pain Relevance 0.47
resulted in an up-regulation of the chemokine receptors CCR3 and CCR5 in HBMECs which in turn may have enhanced the toxic interaction with the viral envelope protein [88].
Positive_regulation (regulation) of chemokine receptors CCR3 associated with chemokine
6) Confidence 0.01 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.78 Pain Relevance 0.11
resulted in an up-regulation of the chemokine receptors CCR3 and CCR5 in HBMECs which in turn may have enhanced the toxic interaction with the viral envelope protein [88].
Positive_regulation (up) of chemokine receptors CCR3 associated with chemokine
7) Confidence 0.01 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.78 Pain Relevance 0.11
resulted in an up-regulation of the chemokine receptors CCR3 and CCR5 in HBMECs which in turn may have enhanced the toxic interaction with the viral envelope protein [88].
Positive_regulation (-) of chemokine receptors CCR3 associated with chemokine
8) Confidence 0.01 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.78 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox