INT226435

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.98
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT6) signal transduction (STAT6) nucleolus (STAT6)
nucleus (STAT6) cytoplasm (STAT6) signal transducer activity (STAT6)
Anatomy Link Frequency
macrophages 1
dendritic cells 1
STAT6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 291 86.88 High High
chemokine 69 70.32 Quite High
Inflammation 294 55.04 Quite High
antagonist 102 5.00 Very Low Very Low Very Low
agonist 60 5.00 Very Low Very Low Very Low
fibrosis 24 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 985 99.84 Very High Very High Very High
Infection 179 98.08 Very High Very High Very High
Occupational Lung Diseases 45 86.08 High High
Organ Transplantation 3 82.96 Quite High
Metaplasia 18 78.16 Quite High
Targeted Disruption 60 76.28 Quite High
Hyperplasia 27 72.48 Quite High
Eosinophilia 61 67.36 Quite High
INFLAMMATION 315 55.04 Quite High
Helminth Infection 44 43.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We thus defined the correlation groups, based on r squared values, in the 5q31 region surrounding the IL13 gene and the 12q13 region surrounding the STAT6 gene.
Regulation (surrounding) of STAT6
1) Confidence 0.37 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.60 Pain Relevance 0
In order to characterize the involvement of IL13 and STAT6 polymorphisms, a new multivariate analysis was done.
Regulation (involvement) of STAT6
2) Confidence 0.37 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.66 Pain Relevance 0.03
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Neg (without) Regulation (affecting) of STAT-6 in dendritic cells
3) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.14
Therefore, although tempting as a target, a clear rationale for targeting STAT-6 in asthma is not currently available.
Regulation (targeting) of STAT-6 associated with asthma
4) Confidence 0.13 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.76 Pain Relevance 0.04
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Neg (without) Regulation (affecting) of STAT-6 in macrophages
5) Confidence 0.07 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.14

General Comments

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