INT226443

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.81
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (STAT4) nucleolus (STAT4) nucleus (STAT4)
cytoplasm (STAT4) signal transducer activity (STAT4)
STAT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 230 98.96 Very High Very High Very High
rheumatoid arthritis 194 98.92 Very High Very High Very High
cytokine 99 90.72 High High
Leflunomide 15 89.12 High High
Inflammation 115 86.16 High High
methotrexate 18 73.60 Quite High
metalloproteinase 1 63.40 Quite High
adenocard 2 54.40 Quite High
Pain 2 52.08 Quite High
corticosteroid 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 216 98.96 Very High Very High Very High
Rheumatoid Arthritis 239 98.92 Very High Very High Very High
Experimental Arthritis 1 97.20 Very High Very High Very High
Disease 88 93.56 High High
Arthritis 18 88.80 High High
INFLAMMATION 118 86.16 High High
Asthma 315 74.48 Quite High
Targeted Disruption 20 66.00 Quite High
Pressure And Volume Under Development 3 52.60 Quite High
Pain 2 52.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this approach we have identified two JIA susceptibility loci, of which one was a novel JIA association (STAT4); while the evidence for a true association for STAT4 is compelling, it will require validation in independent JIA caseĀ–control cohorts, to confirm it as a JIA susceptibility locus.
STAT4 Binding (association) of associated with arthritis
1) Confidence 0.45 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 1.33 Pain Relevance 0.67
STAT4: Four SNPs (rs11889341, rs7574865, rs8179673 and rs10181656) located in the third intron of STAT4, which showed the strongest association with North American and Swedish RA cases13; Korean RA cases24 were also selected.
STAT4 Binding (intron) of associated with rheumatoid arthritis
2) Confidence 0.35 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.78 Pain Relevance 0.39
In the UK population the TRAF1/C5 association did appear stronger in the anti-CCP- positive subgroup than in the negative subgroup,14 however, the strength of association of the STAT4 locus was similar in both subgroups.
STAT4 Binding (association) of
3) Confidence 0.35 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.52 Pain Relevance 0.20
Certainly, STAT4 has been associated with an increased risk of RA and mice lacking STAT4 are resistant to experimental arthritis [68].
STAT4 Binding (associated) of associated with rheumatoid arthritis, experimental arthritis and arthritis
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.62 Pain Relevance 0.61
In addition, IL-21 enhances STAT4 binding to the IFN-?
STAT4 Binding (binding) of
5) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.57 Pain Relevance 0.20

General Comments

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