INT226444

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.32
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL11) extracellular space (CCL11) extracellular region (CCL11)
cell adhesion (CCL11) cytoskeleton organization (CCL11)
Anatomy Link Frequency
eosinophils 1
CCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 150 100.00 Very High Very High Very High
chemokine 28 100.00 Very High Very High Very High
Inflammation 202 98.56 Very High Very High Very High
Inflammatory response 15 82.00 Quite High
adenocard 4 56.32 Quite High
Inflammatory mediators 9 50.00 Quite Low
Inflammatory stimuli 1 44.96 Quite Low
antagonist 36 33.80 Quite Low
agonist 20 5.00 Very Low Very Low Very Low
corticosteroid 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 230 98.56 Very High Very High Very High
Pulmonary Disease 114 97.76 Very High Very High Very High
Disease 51 92.16 High High
Asthma 320 86.88 High High
Necrosis 4 77.80 Quite High
Cancer 6 77.44 Quite High
Infection 21 69.52 Quite High
Hypersensitivity 11 69.52 Quite High
Sprains And Strains 1 68.44 Quite High
Fever 79 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of cytokines involved in the recruitment of eosinophils, such as IL-5, RANTES, and eotaxin could also be a strategy to modify inflammation during COPD exacerbations.
Negative_regulation (Inhibition) of eotaxin in eosinophils associated with pulmonary disease, inflammation and cytokine
1) Confidence 0.41 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.69 Pain Relevance 0.36
Concentrations of IL13, a Th2-associated cytokine, and CCL11/Eotaxin, a Th2-associated chemokine, were suppressed in sera from FP compared to controls (IL13) and AFP (IL13 and CCL11) sera (Figure 4B and Additional File 4, Table S3).
Negative_regulation (suppressed) of CCL11 associated with chemokine and cytokine
2) Confidence 0.31 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.35 Pain Relevance 0.60
Additionally, the BTPs show inhibition of IL-4, IL-5, IL-8, and CCL11 production [150,151].
Negative_regulation (inhibition) of CCL11
3) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.28 Pain Relevance 0.16

General Comments

This test has worked.

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