INT226451

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.45
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NFATC1) DNA binding (NFATC1) cytoplasm (NFATC1)
NFATC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 16 73.92 Quite High
antagonist 49 50.00 Quite Low
cytokine 94 31.12 Quite Low
chemokine 23 20.88 Low Low
Inflammation 102 5.00 Very Low Very Low Very Low
agonist 32 5.00 Very Low Very Low Very Low
Bioavailability 15 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 349 99.76 Very High Very High Very High
Targeted Disruption 20 86.48 High High
Asthma 315 84.60 Quite High
Fibromyalgia 18 82.76 Quite High
Eosinophilia 19 68.00 Quite High
Hyperplasia 9 65.40 Quite High
Metaplasia 6 28.72 Quite Low
Breast Cancer 6 6.08 Low Low
INFLAMMATION 109 5.00 Very Low Very Low Very Low
Hypercalcemia 42 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ICOS costimulation potentiates the TCR-mediated initial IL-4 production, possibly through the enhancement of NFATc1 expression [131].
Spec (possibly) Positive_regulation (enhancement) of Gene_expression (expression) of NFATc1
1) Confidence 0.37 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.42 Pain Relevance 0
B activation followed by induction of NFATc1 expression.
Positive_regulation (induction) of Gene_expression (expression) of NFATc1
2) Confidence 0.30 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.68 Pain Relevance 0.04
At the culture time where control cells differentiate into OCs and show high NFATc1 levels, the RSV analogues at concentrations between 100 nM to 1 ?
Positive_regulation (high) of Gene_expression (levels) of NFATc1 associated with respiratory syncytial virus
3) Confidence 0.22 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.84 Pain Relevance 0
B activation and NFATc1 expression in differentiating OCs.
Positive_regulation (activation) of Gene_expression (expression) of NFATc1
4) Confidence 0.22 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.51 Pain Relevance 0

General Comments

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