INT226459

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.18
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ST2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 192 96.44 Very High Very High Very High
cytokine 182 95.20 Very High Very High Very High
tolerance 2 31.00 Quite Low
antagonist 68 5.00 Very Low Very Low Very Low
chemokine 46 5.00 Very Low Very Low Very Low
agonist 40 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Organ Failure 2 99.56 Very High Very High Very High
Injury 34 99.44 Very High Very High Very High
Targeted Disruption 40 99.16 Very High Very High Very High
Pneumonia 14 96.84 Very High Very High Very High
Asthma 630 94.64 High High
Hypersensitivity 18 92.80 High High
Hemorrhagic Shock 5 88.40 High High
INFLAMMATION 206 68.56 Quite High
Respiratory Syncytial Virus 2 65.76 Quite High
Eosinophilia 38 60.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with this, in transgenic mice with high serum levels of a soluble ST2-Ig recombinant protein, which would be expected to bind to and block the putative ligand, there is minimal reduction in Th2-dependent pulmonary inflammation [301,303].
ST2 Binding (bind) of associated with targeted disruption, inflammation and pneumonia
1) Confidence 0.12 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.95 Pain Relevance 0.15
Recently, the ligand for the most prominent orphan IL-1 receptor, T1/ST2 [295] was found to be IL-33 [296].
ST2 Binding (ligand) of
2) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.58 Pain Relevance 0.16
A recent study of 383 trauma patients at 7 civilian trauma centers has identified the association of a low StO2 with both multiple organ failure and mortality [10].
StO2 Binding (association) of associated with multiple organ failure and injury
3) Confidence 0.05 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 0.65 Pain Relevance 0

General Comments

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