INT226460

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.74
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
Anatomy Link Frequency
macrophages 2
dendritic cells 2
motor nerve 1
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 5 97.52 Very High Very High Very High
Glutamate 40 96.80 Very High Very High Very High
Neurotransmitter 2 96.60 Very High Very High Very High
Neuronal excitability 25 96.56 Very High Very High Very High
cytokine 364 90.00 High High
Inflammation 384 58.16 Quite High
chemokine 92 50.40 Quite High
antagonist 136 5.00 Very Low Very Low Very Low
agonist 81 5.00 Very Low Very Low Very Low
Inflammatory response 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Occupational Lung Diseases 60 91.76 High High
Organ Transplantation 4 86.08 High High
Epilepsy 8 85.80 High High
Neurological Disease 6 85.08 High High
Asthma 1260 76.28 Quite High
Autism 3 76.16 Quite High
Neurofibromatosis 2 75.28 Quite High
Schizophrenia 4 61.08 Quite High
INFLAMMATION 412 58.16 Quite High
Anxiety Disorder 3 51.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of transcription factor in dendritic cells
1) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.43 Pain Relevance 0.11
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of transcription factor in dendritic cells
2) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.50 Pain Relevance 0.17
In this mechanism, activation by the excitatory neurotransmitter glutamate of metabotropic glutamate receptors (mGluRs) located at motor nerve terminals decreases excitability by activating PI3 kinase (PI3K), consequently causing the phosphorylation and inhibition of the transcription factor Foxo.
Phosphorylation (phosphorylation) of transcription factor in motor nerve associated with glutamate, neurotransmitter and glutamate receptor
3) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581892 Disease Relevance 0.88 Pain Relevance 0.42
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of transcription factor in macrophages
4) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.50 Pain Relevance 0.17
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of transcription factor in macrophages
5) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.43 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox