INT226463

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 21.58
Pain Relevance 9.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL23A)
Anatomy Link Frequency
macrophages 6
T cells 5
skin 3
ileum 2
respiratory 2
IL23A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 433 100.00 Very High Very High Very High
rheumatoid arthritis 852 99.90 Very High Very High Very High
psoriasis 451 99.84 Very High Very High Very High
Inflammation 488 98.64 Very High Very High Very High
Crohn's disease 66 98.40 Very High Very High Very High
agonist 26 95.28 Very High Very High Very High
Osteoarthritis 75 92.28 High High
chemokine 62 89.20 High High
spinal inflammation 3 87.84 High High
Arthritis 319 86.76 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 853 99.90 Very High Very High Very High
Psoriasis 550 99.84 Very High Very High Very High
Cancer 157 99.64 Very High Very High Very High
Disease 484 99.20 Very High Very High Very High
Spondylarthritis 6 98.92 Very High Very High Very High
INFLAMMATION 498 98.64 Very High Very High Very High
Infection 262 97.60 Very High Very High Very High
Osteoarthritis 75 92.28 High High
Common Cold 29 88.80 High High
Low Back Pain 3 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A strong and significant upregulation of IL-23p19 transcript was found in the terminal ileum in patients with AS and patients with Crohn's disease (CD).
Positive_regulation (upregulation) of IL-23 in ileum associated with crohn's disease and disease
1) Confidence 0.45 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.79 Pain Relevance 0.81
A strong and significant upregulation of IL-23p19 transcript was found in the terminal ileum in patients with AS and patients with Crohn's disease (CD).
Positive_regulation (upregulation) of IL-23p19 in ileum associated with crohn's disease and disease
2) Confidence 0.45 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.79 Pain Relevance 0.81
Additional data support the role of IL-12 and IL-23 in psoriasis, when genetic studies found associations between certain polymorphisms of the IL-12 receptor (IL-12R) and IL-23R genes and psoriasis.27 It is noteworthy that the sequences/processes depicted above portray a simplified version of what is rather a very complex and intricate model.
Positive_regulation (role) of IL-23 associated with psoriasis
3) Confidence 0.39 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.66 Pain Relevance 0.22
In humans, IL-23 is clearly elevated in psoriatic lesions as indicated by increased levels of both p19 and p40 (subunits of IL-23) mRNA in lesional skin as compared to non-lesional skin, but the mRNA levels of p35 (subunit of IL-12) are not.30 These data suggest that IL-23 appears to play a more dominant role than IL-12 in psoriasis.
Positive_regulation (increased) of p19 in skin associated with psoriasis
4) Confidence 0.36 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.96 Pain Relevance 0.38
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (implicated) of IL-23 in respiratory associated with psoriasis, disease and infection
5) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.25 Pain Relevance 0.30
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (dependent) of IL-23 in respiratory associated with psoriasis, disease and infection
6) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.25 Pain Relevance 0.30
This kind of analysis is considered a conservative method, so the outstanding long-term efficacy rates yielded by those studies could possibly be underestimation of the real potential of this IL-12 and IL-23 inhibitor.42
Positive_regulation (potential) of IL-23
7) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.55 Pain Relevance 0.15
This mechanism allows for the inhibition of naïve T-cells, which requires IL-12 and IL-23 for differentiation, proliferation, and effector function.
Positive_regulation (requires) of IL-23 in T-cells
8) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.51 Pain Relevance 0.23
In humans, IL-23 is clearly elevated in psoriatic lesions as indicated by increased levels of both p19 and p40 (subunits of IL-23) mRNA in lesional skin as compared to non-lesional skin, but the mRNA levels of p35 (subunit of IL-12) are not.30 These data suggest that IL-23 appears to play a more dominant role than IL-12 in psoriasis.
Positive_regulation (elevated) of IL-23 in skin associated with psoriasis
9) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.03 Pain Relevance 0.39
In humans, IL-23 is clearly elevated in psoriatic lesions as indicated by increased levels of both p19 and p40 (subunits of IL-23) mRNA in lesional skin as compared to non-lesional skin, but the mRNA levels of p35 (subunit of IL-12) are not.30 These data suggest that IL-23 appears to play a more dominant role than IL-12 in psoriasis.
Positive_regulation (increased) of IL-23 in skin associated with psoriasis
10) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.02 Pain Relevance 0.40
However, our data are consistent with recent evidence showing that bioactive IL-23 (p19/p40) was barely detectable in joints of patients with RA [47].
Positive_regulation (bioactive) of p19 in joints associated with rheumatoid arthritis
11) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.33 Pain Relevance 0.14
Following activation with PGN, there was a 15-fold increase of IL-23 mRNA in the control macrophages, but a significantly greater increase (p < 0.01) of 621-fold in the RA SF macrophages.
Positive_regulation (increase) of IL-23 mRNA in macrophages associated with rheumatoid arthritis
12) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.41 Pain Relevance 0.70
However, IL-23 mRNA was significantly increased in RA SF macrophages compared with control macrophages, with or without TLR2 ligation.
Positive_regulation (increased) of IL-23 mRNA in macrophages associated with rheumatoid arthritis
13) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575607 Disease Relevance 1.59 Pain Relevance 0.79
Although IL-23 was rarely detected in RA SF, IL-23 mRNA was increased in RA SF macrophages compared with control macrophages, in the absence or presence of the toll-like receptor (TLR) 2 agonist, PGN.
Positive_regulation (increased) of IL-23 mRNA in macrophages associated with agonist and rheumatoid arthritis
14) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.54 Pain Relevance 0.86
Further, RA SF macrophages stimulated with PGN expressed significantly higher levels of IL-23 mRNA compared with control macrophages treated similarly.
Positive_regulation (levels) of IL-23 mRNA in macrophages associated with rheumatoid arthritis
15) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.03 Pain Relevance 0.55
are expressed in RA SF macrophages, their induction after TLR2 ligation was less compared with the induction of IL-23 in RA SF macrophages.


Positive_regulation (induction) of IL-23 in macrophages associated with rheumatoid arthritis
16) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.09 Pain Relevance 0.54
This phenotype is characterized by high capacity to present antigens and high capacity to produce IL-12 (promoting Th1 responses) and IL-23 (promoting maturation and survival of IL-17 producing T cells), as well as microbicidal nitric oxide and reactive oxygen intermediates.
Positive_regulation (promoting) of IL-23 in T cells
17) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.48 Pain Relevance 0.21
This phenotype is characterized by high capacity to present antigens and high capacity to produce IL-12 (promoting Th1 responses) and IL-23 (promoting maturation and survival of IL-17 producing T cells), as well as microbicidal nitric oxide and reactive oxygen intermediates.
Positive_regulation (promoting) of IL-23 in T cells
18) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.48 Pain Relevance 0.21
IL-12 and IL-23 are two heterodimeric cytokines that share the p40 chain to become biologically active.
Positive_regulation (active) of IL-23 associated with cytokine
19) Confidence 0.14 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.34 Pain Relevance 0.08
The origin of TH17 cells is controversial: in human, TH17 cells originate from CD161+ naive CD4+ T-cells precursor, which constitutively express RORgammat and IL-23R, in response to the combined activity of IL-1beta and IL-23.
Positive_regulation (response) of IL-23 in T-cells
20) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.71 Pain Relevance 0.39

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