INT226467

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.60
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
macrophages 1
dendritic cells 1
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 214 99.76 Very High Very High Very High
Inflammation 192 56.84 Quite High
chemokine 46 49.08 Quite Low
antagonist 68 5.00 Very Low Very Low Very Low
agonist 40 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 94.68 High High
Leishmaniasis 33 93.44 High High
Organ Transplantation 2 84.76 Quite High
Occupational Lung Diseases 30 84.08 Quite High
Recurrence 21 82.20 Quite High
Asthma 630 74.96 Quite High
INFLAMMATION 206 56.84 Quite High
Apoptosis 18 36.72 Quite Low
Targeted Disruption 40 5.00 Very Low Very Low Very Low
Eosinophilia 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antigen-specific lymphoproliferation and Th1-type cytokine analysis before and 1-week after Fungisome treatment
Phosphorylation (lymphoproliferation) of Th1 associated with cytokine
1) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.62 Pain Relevance 0.19
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of Th1 in dendritic cells
2) Confidence 0.26 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.49 Pain Relevance 0.14
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of Th1 in macrophages
3) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.49 Pain Relevance 0.14

General Comments

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