INT226469

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL4R) extracellular space (IL4R) extracellular region (IL4R)
plasma membrane (IL4R)
IL4R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 34 99.00 Very High Very High Very High
Inflammation 96 85.60 High High
cytokine 91 40.96 Quite Low
chemokine 23 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 315 89.72 High High
INFLAMMATION 103 86.32 High High
Hyperplasia 9 84.56 Quite High
Occupational Lung Diseases 15 69.20 Quite High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 67.20 Quite High
Pulmonary Eosinophilia 1 43.40 Quite Low
Rhinitis 11 37.40 Quite Low
Targeted Disruption 20 31.76 Quite Low
Eosinophilia 19 26.64 Quite Low
Pneumonia 7 14.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-4 muteins act as antagonists for both IL4 and IL-13, because they are able to bind to IL-4R/IL13R, but do not transduce the signal.
IL-4R Binding (bind) of associated with antagonist
1) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.94 Pain Relevance 0.13

General Comments

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