INT226471

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.88
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ST2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 102 99.20 Very High Very High Very High
cytokine 95 98.16 Very High Very High Very High
tolerance 1 84.16 Quite High
Sciatic nerve 1 69.44 Quite High
antagonist 34 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 109 99.20 Very High Very High Very High
Injury 34 96.16 Very High Very High Very High
Contusions 1 93.04 High High
Soft Tissue Injuries 2 89.52 High High
Death 21 88.00 High High
Hypotension 4 88.00 High High
Lacerations 1 86.24 High High
Fistula 1 78.76 Quite High
Infection 6 76.64 Quite High
Eosinophilia 19 76.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, this effect is blocked by prior treatment with the JNK inhibitor SP600125 confirming that JNK as a key effector in T1/ST2 signaling [306].
Negative_regulation (effector) of ST2
1) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.15 Pain Relevance 0.12
In the ED he received 2 liters of LR and 1 unit of O negative PRBCs with an improvement of his vital signs and StO2 (SBP 110 mm Hg, HR 125/min, StO2 71%).
Negative_regulation (improvement) of StO2
2) Confidence 0.06 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 1.19 Pain Relevance 0.03
After 1 h exposure to L. plantarum, interleukin-1 (IL-1), IL-1 receptors IL-1R and IL-1-like receptor IL1RL1 (ST2) were downregulated.
Negative_regulation (downregulated) of ST2
3) Confidence 0.06 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.54 Pain Relevance 0.13

General Comments

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