INT226475

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (STAT4) nucleolus (STAT4) nucleus (STAT4)
cytoplasm (STAT4) signal transducer activity (STAT4)
Anatomy Link Frequency
joints 1
NK cells 1
STAT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 77 96.32 Very High Very High Very High
Arthritis 2 94.24 High High
cytokine 99 94.12 High High
methotrexate 18 93.76 High High
Inflammation 109 91.52 High High
Leflunomide 15 78.68 Quite High
metalloproteinase 1 52.96 Quite High
Pain 2 41.64 Quite Low
corticosteroid 3 39.56 Quite Low
antagonist 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 122 98.20 Very High Very High Very High
Experimental Arthritis 1 94.24 High High
INFLAMMATION 115 91.52 High High
Disease 46 66.88 Quite High
Asthma 315 64.88 Quite High
Epstein-barr Virus 1 56.60 Quite High
Hypersensitivity 9 49.56 Quite Low
Pressure And Volume Under Development 3 42.16 Quite Low
Pain 2 41.64 Quite Low
Eosinophilia 19 29.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STAT4 expression in joints of patients with ERA has been reported [69] and here we show that prednisone may function in part by blocking STAT4 activation.
Positive_regulation (activation) of STAT4 in joints associated with rheumatoid arthritis
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.58 Pain Relevance 0.56
production from NK cells and promotes Th1 differentiation through the induction of T-bet and the activation of STAT4.
Positive_regulation (activation) of STAT4 in NK cells
2) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.43 Pain Relevance 0.22

General Comments

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