INT226480

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.96
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK3) cytoskeleton (JAK3) cytoplasm (JAK3)
Anatomy Link Frequency
lymphocyte 1
JAK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 131 99.98 Very High Very High Very High
corticosteroid 78 77.28 Quite High
abatacept 5 77.12 Quite High
Bioavailability 12 66.00 Quite High
adenocard 2 59.44 Quite High
Inflammation 116 42.08 Quite Low
Leflunomide 2 36.64 Quite Low
rheumatoid arthritis 1 10.16 Low Low
psoriasis 2 8.16 Low Low
antagonist 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 14 94.28 High High
Asthma 315 79.52 Quite High
Anaemia 9 79.44 Quite High
Severe Combined Immunodeficiency 2 71.84 Quite High
Targeted Disruption 20 57.92 Quite High
Neointima 2 56.12 Quite High
Cytomegalovirus Infection 17 51.64 Quite High
Graft Vs Host Disease 2 50.00 Quite Low
INFLAMMATION 123 42.08 Quite Low
Disease 33 41.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-21 binding stimulates activation of Janus kinase (JAK)1/JAK3 and then preferentially activates STAT-1 and STAT-3 [263].
Positive_regulation (activation) of JAK3
1) Confidence 0.45 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.18
Stimulation of JAK-3, a cytoplasmic tyrosine kinase, leads to dimerization of STAT 5 transcription factor which is specific for the IL-2 family of cytokines and hence make this a potential target for immunosuppressive drugs [128].
Positive_regulation (Stimulation) of JAK-3 associated with cytokine
2) Confidence 0.24 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.14 Pain Relevance 0.30
JAK-1 and JAK-2 are activated by a broad range of cytokines that use gp130 whereas JAK-3 which is highly expressed in lymphoid cells is activated only by cytokines that bind to gamma-chain-containing receptors.
Positive_regulation (activated) of JAK-3 associated with cytokine
3) Confidence 0.16 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.25 Pain Relevance 0.30
These cytokines activate the mTOR via the janus kinase 3 and phosphoinositide-3 kinase signal transduction pathways, leading to further propagation of the lymphocyte cell cycle.
Positive_regulation (activate) of janus kinase 3 in lymphocyte associated with cytokine
4) Confidence 0.07 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998809 Disease Relevance 0.09 Pain Relevance 0.18

General Comments

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