INT226481

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (GATA3) anatomical structure formation involved in morphogenesis (GATA3) DNA binding (GATA3)
signal transduction (GATA3) nucleolus (GATA3) nucleus (GATA3)
Anatomy Link Frequency
lung 2
Th2 cell 2
GATA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 192 100.00 Very High Very High Very High
cytokine 182 100.00 Very High Very High Very High
agonist 40 87.60 High High
dexamethasone 2 76.96 Quite High
Inflammatory response 12 45.84 Quite Low
antagonist 68 5.00 Very Low Very Low Very Low
chemokine 46 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilia 38 100.00 Very High Very High Very High
Pneumonia 14 100.00 Very High Very High Very High
INFLAMMATION 206 98.28 Very High Very High Very High
Asthma 630 96.64 Very High Very High Very High
Targeted Disruption 40 92.64 High High
Hyperplasia 18 83.28 Quite High
Necrosis 2 49.68 Quite Low
Cancer 6 49.32 Quite Low
Epstein-barr Virus 2 16.08 Low Low
Hypersensitivity 18 15.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro IL-27 also inhibits Th2 cell differentiation through decreased expression of GATA-3 and subsequent reduction in IL-4 production [284,285].
Negative_regulation (decreased) of Gene_expression (expression) of GATA-3 in Th2 cell
1) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.61 Pain Relevance 0.23
ligands also decrease antigen-induced airway hyperresponsiveness, lung inflammation and eosinophilia, cytokine production, and GATA-3 expression as well as serum levels of antigen-specific IgE in many different animal models of asthma [163,167-170].
Negative_regulation (decrease) of Gene_expression (expression) of GATA-3 in lung associated with asthma, inflammation, pneumonia, eosinophilia and cytokine
2) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.80 Pain Relevance 0.35

General Comments

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