INT226482

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
macrophages 1
dendritic cells 1
bladder 1
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 202 90.88 High High
Inflammation 193 59.04 Quite High
chemokine 46 51.28 Quite High
palliative 1 7.20 Low Low
antagonist 68 5.00 Very Low Very Low Very Low
agonist 40 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 1 95.60 Very High Very High Very High
Organ Transplantation 2 86.96 High High
Occupational Lung Diseases 30 84.08 Quite High
Cancer 185 78.28 Quite High
Asthma 630 77.16 Quite High
Lymphopenia 5 74.72 Quite High
INFLAMMATION 207 59.04 Quite High
Carcinoma 2 50.00 Quite Low
Apoptosis 19 38.92 Quite Low
Melanoma 4 23.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, in preclinical studies, a coformulation of IL-12 with chitosan intravesically delivered was well tolerated and very efficient at curing mice with superficial bladder cancer.
Phosphorylation (coformulation) of IL-12 in bladder associated with bladder cancer
1) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.46 Pain Relevance 0.18
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of IL-12-induced in dendritic cells
2) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.50 Pain Relevance 0.20
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Phosphorylation (phosphorylation) of IL-12-induced in macrophages
3) Confidence 0.03 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.50 Pain Relevance 0.20

General Comments

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