INT226580

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.52
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK1) cytoskeleton (JAK1) nucleus (JAK1)
cytoplasm (JAK1)
Anatomy Link Frequency
blood 1
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 31 98.70 Very High Very High Very High
Potency 27 98.12 Very High Very High Very High
Pain 5 54.24 Quite High
headache 2 52.96 Quite High
Inflammation 21 50.00 Quite Low
Arthritis 48 30.64 Quite Low
rheumatoid arthritis 22 29.52 Quite Low
Opioid 2 10.72 Low Low
Analgesic 1 9.36 Low Low
dexamethasone 1 6.64 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 4 91.68 High High
Myelodysplastic Syndromes 18 74.32 Quite High
Congenital Anomalies 6 71.28 Quite High
Toxicity 11 67.04 Quite High
Small Cell Lung Cancer 5 57.36 Quite High
Pain 5 54.24 Quite High
Headache 2 52.96 Quite High
Fatigue 4 51.36 Quite High
Neutropenia 24 50.00 Quite Low
INFLAMMATION 20 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downstream signalling occurs mainly via the Ras/Raf/MAP kinase pathway, the phosphatidyl-inositol phosphate kinase (PIP Kinase/PI-3K)/AKT pathway, and the JAK/STAT nuclear translocation.
Localization (translocation) of JAK
1) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.16 Pain Relevance 0
Thus, while CP-690,550 can inhibit cytokine activation pathways associated with JAK1, subtle differences in JAK or STAT utilization by specific receptors may influence inhibitor potency and selectivity.
Localization (utilization) of JAK associated with potency and cytokine
2) Confidence 0.05 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.39
Despite their chemical differences, all of these molecules interact with the g-csf receptor and initiate downstream signalling through the jak–stat (Janus kinase–signal transducers and activators of transcription) intracellular pathway 79, thus enhancing the activity, production, and release of neutrophils into the peripheral blood.
Localization (release) of Janus in blood
3) Confidence 0.01 Published 2008 Journal Current Oncology Section Body Doc Link PMC2259432 Disease Relevance 0.36 Pain Relevance 0.11

General Comments

This test has worked.

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