INT22662

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Context Info
Confidence 0.41
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 4.68
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aldh3a1) oxidoreductase activity (Aldh3a1) endoplasmic reticulum (Aldh3a1)
cytoplasm (Aldh3a1)
Anatomy Link Frequency
CPA 2
Aldh3a1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 65 97.04 Very High Very High Very High
Bioavailability 1 95.40 Very High Very High Very High
alcohol 21 92.28 High High
Enkephalin 2 89.20 High High
Potency 9 76.40 Quite High
fibrosis 2 59.40 Quite High
Angina 11 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1010 98.84 Very High Very High Very High
Stress 61 98.52 Very High Very High Very High
Sprains And Strains 3 96.92 Very High Very High Very High
Targeted Disruption 48 94.36 High High
Colorectal Cancer 128 94.16 High High
Death 14 93.08 High High
Kyphosis 2 87.36 High High
Osteoporosis 2 86.96 High High
Acute Promyelocytic Leukemia 4 83.28 Quite High
Hematological Disease 4 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Individual injection of chlorpromazine or reserpine inhibited only albino ICR T-ALDH which was alleviated by pretreatment with amantadine and, thereby, suggesting antagonism between amantadine and these agents.
Negative_regulation (inhibited) of ALDH
1) Confidence 0.41 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2315366 Disease Relevance 0.27 Pain Relevance 0.26
As in vitro experiments suggest, inhibition of ALDH activity in vivo sensitizes tumors to CPA therapy; however, the half-life of DEAB in vivo is extremely short [42] and such studies cannot be done.
Negative_regulation (inhibition) of ALDH in CPA associated with cancer
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.49 Pain Relevance 0
Like DEAB, retinoic acid (a vitamin A/retinaldehyde metabolite and product of ALDH activity) appears to decrease ALDH1 and ALDH3 protein levels via a feedback mechanism that can sensitize cells to CPA-induced cytotoxicity [23], [43].
Spec (appears) Negative_regulation (decrease) of ALDH3 in CPA
3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.69 Pain Relevance 0
Like DEAB, all-trans retinoic acid (ATRA) has been demonstrated to reduce ALDH enzyme activity; however, it does so by reducing ALDH1 and ALDH3 protein levels [43].
Negative_regulation (reducing) of ALDH3
4) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.59 Pain Relevance 0
Like DEAB, all-trans retinoic acid (ATRA) has been demonstrated to reduce ALDH enzyme activity; however, it does so by reducing ALDH1 and ALDH3 protein levels [43].
Negative_regulation (reduce) of ALDH enzyme
5) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.65 Pain Relevance 0
Moreover, oxidative inhibition of prostacyclin synthase [18] as well as mitochondrial ALDH activity [22] may present other key events in the development of nitrate tolerance.
Negative_regulation (inhibition) of ALDH associated with tolerance
6) Confidence 0.16 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.16 Pain Relevance 0.37
As negative control, 1 ml of the sample was treated with 5 ┬Ál of 1.5 mM DEAB (diethylaminobenzaldehyde), a specific ALDH inhibitor.
Negative_regulation (inhibitor) of ALDH
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
This metabolic remodelling was attributed to increased glutathione biosynthesis to compensate for the diminished ALDH activity and the elevated oxidative stress.
Negative_regulation (diminished) of ALDH associated with stress
8) Confidence 0.11 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.73 Pain Relevance 0.05
In these mice, expression of the dominant-negative ALDH2*2 resulted in impaired ALDH activity when using a variety of aldehydic substrates.
Negative_regulation (impaired) of ALDH
9) Confidence 0.11 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 1.02 Pain Relevance 0.13
The specificity of this reaction was verified by applying the ALDH inhibitor DEAB, which completely blocked BAAA conversion (Figure 12A, left panel).
Negative_regulation (inhibitor) of ALDH
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.08 Pain Relevance 0

General Comments

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