INT226622

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 32 5.00 Very Low Very Low Very Low
imagery 16 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 600 99.46 Very High Very High Very High
Infection 80 69.20 Quite High
Cytomegalovirus Infection 8 22.36 Low Low
Superinfection 32 5.00 Very Low Very Low Very Low
Apoptosis 32 5.00 Very Low Very Low Very Low
Cancer 24 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that PMA induces internalization and lysosomal degradation of CD4.
Positive_regulation (induces) of Protein_catabolism (degradation) of CD4
1) Confidence 0.37 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.53 Pain Relevance 0
PMA-induced lysosomal degradation of CD4 is independent of TSG101 and Vps4
Positive_regulation (induced) of Protein_catabolism (degradation) of CD4
2) Confidence 0.37 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.54 Pain Relevance 0
PMA-induced lysosomal degradation of CD4 is independent of TSG101 and Vps4
Neg (independent) Positive_regulation (independent) of Protein_catabolism (degradation) of CD4
3) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.54 Pain Relevance 0
PMA-induced CD4 degradation was not affected by either depletion of endogenous TSG101 or by overexpression of Vps4E228Q or HIV-1 Gag, suggesting that under these conditions, lysosomal degradation of CD4 can proceed in the absence of ESCRT-I and Vps4.
Positive_regulation (induced) of Protein_catabolism (degradation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.44 Pain Relevance 0
A summary of all the measurements of PMA-induced CD4 degradation represented as the percent of undegraded CD4 remaining after 6 hours of PMA treatment is shown in Fig. 5B.
Positive_regulation (-) of Protein_catabolism (degradation) of CD4
5) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.36 Pain Relevance 0
A summary of all the measurements of PMA-induced CD4 degradation represented as the percent of undegraded CD4 remaining after 6 hours of PMA treatment is shown in Fig. 5B.
Positive_regulation (induced) of Protein_catabolism (degradation) of CD4
6) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.36 Pain Relevance 0
Taken together, these findings suggest that PMA-induced CD4 degradation may be partially dependent on TSG101 and Vps4 function and only during early times after exposure to PMA.
Positive_regulation (induced) of Protein_catabolism (degradation) of CD4
7) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.16 Pain Relevance 0
Expression of HIV-1 Gag does not affect PMA-induced CD4 degradation
Positive_regulation (induced) of Protein_catabolism (degradation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.20 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox