INT226634

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 6.83
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 17 85.12 High High
chemokine 17 79.36 Quite High
Kinase C 68 5.00 Very Low Very Low Very Low
imagery 34 5.00 Very Low Very Low Very Low
Opioid 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1275 99.62 Very High Very High Very High
Infection 170 92.04 High High
INFLAMMATION 17 84.76 Quite High
Cytomegalovirus Infection 17 66.32 Quite High
Superinfection 68 5.00 Very Low Very Low Very Low
Apoptosis 68 5.00 Very Low Very Low Very Low
Cancer 51 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, cells expressing the late domain mutant, LTAL Gag-GFP, exhibited CXCR4 degradation rates more similar to the LacZ control (Fig 3D,E).
Protein_catabolism (degradation) of CXCR4
1) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.78 Pain Relevance 0
These data are similar to those reported in Figure 2, for SDF-I induced HA-CXCR4 degradation.


Protein_catabolism (degradation) of CXCR4
2) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.54 Pain Relevance 0
Indeed, in order to observe SDF-1 induced CXCR4 degradation in Jurkat cells, we needed to inhibit the synthesis of new receptors continuously with cycloheximide and incubate the cells with SDF-1, PMA and ionomycin (Fig. 3A).
Protein_catabolism (degradation) of CXCR4
3) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 1.00 Pain Relevance 0
While Hrs and Vps4 have been implicated in the lysosomal degradation of monoubiquitylated CXCR4 [20], no study has determined whether the ESCRT complexes play a role in this process.
Protein_catabolism (degradation) of CXCR4
4) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.34 Pain Relevance 0.08
Expression of HIV-1 Gag inhibits HA-CXCR4 degradation in a late-domain dependent manner
Protein_catabolism (degradation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.32 Pain Relevance 0
In contrast, cells that were incubated in the presence of SDF-1 clearly exhibited a loss in receptor signal, confirming that SDF-1 induces degradation of HA-CXCR4.
Protein_catabolism (degradation) of CXCR4
6) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.05 Pain Relevance 0
COS-1 cells overexpressing TSG101 also exhibited attenuated HA-CXCR4 degradation (Fig. 1A).
Protein_catabolism (degradation) of CXCR4
7) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.22 Pain Relevance 0
SDF-1 induced HA-CXCR4 degradation was significantly attenuated in TSG101-deficient cells (Fig. 1A), as indicated by the retention of receptors in punctate structures even after 3 hours of incubation with SDF-1.
Protein_catabolism (degradation) of CXCR4
8) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.05 Pain Relevance 0
Cells expressing wild type HIV-1 Gag-GFP exhibited attenuated HA-CXCR4 degradation (Fig 2A).
Protein_catabolism (degradation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.51 Pain Relevance 0
Since SDF-1 induced degradation of HA-CXCR4 also appears to be ESCRT-I dependent, we hypothesized that HA-CXCR4 degradation would also be attenuated in HIV-1 Gag expressing cells.
Protein_catabolism (degradation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.57 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.52 Pain Relevance 0
HA-CXCR4 that was internalized in the absence of SDF-1 appeared in punctate, endosomal structures and remained undegraded.
Protein_catabolism (undegraded) of CXCR4
11) Confidence 0.51 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.12 Pain Relevance 0
Previous studies have established that SDF-1 induces internalization, endosomal trafficking and lysosomal degradation of CXCR4 and HA-tagged CXCR4 in a variety of cell types [19,20,30].
Protein_catabolism (degradation) of CXCR4
12) Confidence 0.38 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.32 Pain Relevance 0
Since SDF-1 induced degradation of HA-CXCR4 also appears to be ESCRT-I dependent, we hypothesized that HA-CXCR4 degradation would also be attenuated in HIV-1 Gag expressing cells.
Protein_catabolism (degradation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.38 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.52 Pain Relevance 0
Cells expressing a Gag PTAP mutant efficiently degraded HA-CXCR4 (Fig. 2A).
Protein_catabolism (degraded) of CXCR4
14) Confidence 0.38 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.52 Pain Relevance 0
Previous studies have established that SDF-1 induces internalization, endosomal trafficking and lysosomal degradation of CXCR4 and HA-tagged CXCR4 in a variety of cell types [19,20,30].
Protein_catabolism (degradation) of CXCR4
15) Confidence 0.38 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.32 Pain Relevance 0
HA-CXCR4 has previously been shown to be a valid marker for CXCR4 trafficking and degradation in COS-1 cells [19,20].
Protein_catabolism (degradation) of CXCR4
16) Confidence 0.38 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.27 Pain Relevance 0
In contrast, CXCR4 degradation in cells expressing the late domain mutant, LTAL Gag-GFP was nearly equivalent to that of control cells (Fig 2B).
Protein_catabolism (degradation) of CXCR4
17) Confidence 0.38 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.42 Pain Relevance 0

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