INT226637

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 41
Total Number 45
Disease Relevance 24.42
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
kidney 3
T cells 3
HSC 2
bone marrow 1
granule cell 1
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 112 98.32 Very High Very High Very High
ischemia 31 94.20 High High
Hippocampus 105 93.68 High High
Kinase C 116 89.12 High High
Inflammation 34 86.40 High High
cytokine 21 85.36 High High
antagonist 6 85.04 High High
Central nervous system 21 84.24 Quite High
Inflammatory response 30 71.64 Quite High
imagery 85 66.28 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2175 100.00 Very High Very High Very High
Metastasis 343 99.92 Very High Very High Very High
Injury 205 99.72 Very High Very High Very High
Apoptosis 190 99.48 Very High Very High Very High
Macroglobulinemia 14 99.44 Very High Very High Very High
Superinfection 116 99.16 Very High Very High Very High
Lymphatic System Cancer 36 98.60 Very High Very High Very High
Infection 290 97.24 Very High Very High Very High
Hypoxia 239 96.52 Very High Very High Very High
Chronic Lymphoid Leukemia 7 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to investigate the involvement of the SDF-1/ CXCR4-axis in the migration of HSC to the injured kidney, we utilized two independent approaches to inhibit SDF-1/CXCR4 function.
Negative_regulation (inhibit) of CXCR4 in kidney
1) Confidence 0.48 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.06 Pain Relevance 0
To test this hypothesis, we blocked CXCR4 activity by infusing mice with AMD3100 via osmotic minipumps implanted subcutaneously.
Negative_regulation (blocked) of CXCR4
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.83 Pain Relevance 0.10
In WM, we observed a significant CXCR4 down-regulation in comparison to other NHL types (Figure 1).
Negative_regulation (down) of CXCR4 associated with macroglobulinemia and lymphatic system cancer
3) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 1.25 Pain Relevance 0
Tögel et al. also observed a selective homing of exogenous administered BMC to the injured kidney and could inhibit this by blocking bone marrow-associated CXCR4 [18].
Negative_regulation (blocking) of CXCR4 in kidney
4) Confidence 0.35 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.44 Pain Relevance 0.07
In addition, in separate groups of acceptor mice, endogenous SDF-1 or HSC-associated CXCR4 was blocked or kidneys were injected with SDF-1.
Negative_regulation (blocked) of CXCR4 in HSC
5) Confidence 0.35 Published 2009 Journal Nephrology Dialysis Transplantation Section Abstract Doc Link PMC2698094 Disease Relevance 0.24 Pain Relevance 0.08
In immune-deficient mice, the SDF-1/CXCR4-axis is essential for efficient homing of human stem cells as indicated by the impaired repopulation of the bone marrow after blocking stem cell-associated CXCR4 [11–13].
Negative_regulation (blocking) of CXCR4 in stem cell
6) Confidence 0.35 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.51 Pain Relevance 0.08
In contrast to other studies [11,13,18,21], we were unable to significantly influence the migration of HSC to the ischemic injured kidney by blocking the SDF-1/CXCR4-axis.
Negative_regulation (blocking) of CXCR4 in kidney
7) Confidence 0.35 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0 Pain Relevance 0
In addition, our in vitro and in vivo HSC migration assays demonstrated a decreased migration towards high recSDF-1 levels and bone marrow, respectively, after neutralizing SDF-1 or CXCR4.
Negative_regulation (neutralizing) of CXCR4 in bone marrow
8) Confidence 0.35 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.22 Pain Relevance 0.03
Our studies suggest that at least part of the mechanism for guiding new cells to their final position in the granule cell layer is the expression of CXCL12, as ESNPs show a directional migration toward a source of this chemokine in vitro, and their migration is truncated in vivo after infusion with AMD3100, an inhibitor of CXCR4.
Negative_regulation (inhibitor) of CXCR4 in granule cell associated with chemokine
9) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.52 Pain Relevance 0.33
In order to block CXCR4 receptors, ESNPs were first incubated in varying amounts of AMD3100 (Sigma) for 30 min. at room temperature, washed in PBS and then resuspended in DMEM/F12.
Negative_regulation (block) of CXCR4
10) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0
Thus, CXCR4 downregulation might not be essential for HIV-1 replication.
Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.85 Pain Relevance 0.03
Identifying which of the two Hrs-dependent pathways is functional in the lysosomal downregulation of CXCR4 is important since this may also have implications for the trafficking of this receptor in HIV-1 infected cells.
Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.33 Pain Relevance 0.07
A recent study reported that HIV-1 Nef induces downregulation of CXCR4 from the cell surface of infected cells [50].
Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.81 Pain Relevance 0
Our data (Figs 1, 2) strongly suggest that SDF-1 induced CXCR4 downregulation is TSG101 and ESCRT-I dependent.
Negative_regulation (downregulation) of CXCR4
14) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.38 Pain Relevance 0
HIV-1 Gag attenuates SDF-1 induced downregulation of endogenous CXCR4 in Jurkat T cells
Negative_regulation (downregulation) of CXCR4 in T cells associated with acquired immune deficiency syndrome or hiv infection
15) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.59 Pain Relevance 0
Incubation of Gag-GFP expressing Jurkat cells with SDF-1, PMA and ionomycin revealed that downregulation of endogenous CXCR4 was clearly attenuated by expression of wt Gag-GFP (Fig. 3C,D,E).
Negative_regulation (downregulation) of CXCR4
16) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.82 Pain Relevance 0
Our observations that TSG101/ESCRT-I dependent downregulation of CXCR4 (Figs 2, 3) and EGFR [14] are attenuated in HIV-1 Gag expressing cells indicate that Gag functionally depletes the ESCRT complexes, thereby interrupting other ESCRT-dependent pathways in the cell.
Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.55 Pain Relevance 0
We speculate that during the late stages of the viral life cycle when mostly structural proteins such as Gag are expressed, SDF-1 induced CXCR4 downregulation is attenuated resulting in the accumulation of densensitized CXCR4 within intracellular compartments.
Negative_regulation (downregulation) of CXCR4
18) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.74 Pain Relevance 0.13
In order to determine whether SDF-1 induced HA-CXCR4 downregulation is dependent on the ESCRT-I complex, cells were depleted of the critical ESCRT-I component, TSG101.
Spec (whether) Negative_regulation (downregulation) of CXCR4
19) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0
In order to determine whether downregulation of other receptors is sensitive to HIV-1 Gag expression, we have now investigated the kinetics of lysosomal downregulation of CD4 and CXCR4, in the presence and absence of Gag.
Spec (investigated) Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.61 Pain Relevance 0.06

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