INT226641

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 20
Disease Relevance 6.12
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
tail 1
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 80 98.88 Very High Very High Very High
Opioid 20 70.08 Quite High
Inflammatory response 20 44.56 Quite Low
chemokine 20 38.80 Quite Low
imagery 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1500 99.30 Very High Very High Very High
Infection 200 90.96 High High
Superinfection 80 78.40 Quite High
Apoptosis 80 65.76 Quite High
INFLAMMATION 20 44.20 Quite Low
Cytomegalovirus Infection 20 21.64 Low Low
Cancer 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have quantitated CD4 degradation kinetics by monitoring levels of metabolically (pulse) labeled CD4 over time in untreated and PMA-treated cells [24,33,34].
Protein_catabolism (degradation) of CD4
1) Confidence 0.53 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.43 Pain Relevance 0
Previous studies have shown that PMA induces internalization and lysosomal degradation of CD4.
Protein_catabolism (degradation) of CD4
2) Confidence 0.53 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.52 Pain Relevance 0
We therefore predict that lysosomal degradation of CD4 should not be impeded by Gag in an HIV-1 infected cell.
Protein_catabolism (degradation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.53 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.66 Pain Relevance 0.14
PMA-induced lysosomal degradation of CD4 is independent of TSG101 and Vps4
Protein_catabolism (degradation) of CD4
4) Confidence 0.53 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.54 Pain Relevance 0
Expression of HIV-1 Gag does not affect PMA-induced CD4 degradation
Protein_catabolism (degradation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.20 Pain Relevance 0
However, by 6 hours, CD4 was degraded as efficiently in TSG101-depleted cells as in control cells.
Protein_catabolism (degraded) of CD4
6) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0
Activated PKC phosphorylates CD4 on its cytoplasmic tail and induces CD4 internalization and lysosomal degradation [25,59].
Protein_catabolism (degradation) of CD4 in tail associated with kinase c
7) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.39 Pain Relevance 0.19
Similarly, the HIV-1 Nef protein induces endocytosis and lysosomal degradation of CD4 [26].
Protein_catabolism (degradation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.23 Pain Relevance 0
Thus, our observations imply that CXCR4, but not CD4, is dependent on the ESCRT-I complex for its lysosomal degradation.
Protein_catabolism (degradation) of CD4
9) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.35 Pain Relevance 0.07
PMA-induced CD4 degradation was not affected by either depletion of endogenous TSG101 or by overexpression of Vps4E228Q or HIV-1 Gag, suggesting that under these conditions, lysosomal degradation of CD4 can proceed in the absence of ESCRT-I and Vps4.
Protein_catabolism (degradation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.53 Pain Relevance 0
PMA-induced CD4 degradation was not affected by either depletion of endogenous TSG101 or by overexpression of Vps4E228Q or HIV-1 Gag, suggesting that under these conditions, lysosomal degradation of CD4 can proceed in the absence of ESCRT-I and Vps4.
Protein_catabolism (degradation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.44 Pain Relevance 0
At early time points, CD4 degradation was slightly attenuated, but by 6 h, Vps4E228Q-GFP expressing cells had degraded CD4 as efficiently as cells expressing GFP (Fig. 4C).
Protein_catabolism (degraded) of CD4
12) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.12 Pain Relevance 0
Gag expressing cells, like TSG101-depleted and Vps4E228Q overexpressing cells, exhibited an initial slowdown in the rate of CD4 degradation, which was completely overcome upon prolonged exposure to PMA (Fig. 5A).
Protein_catabolism (degradation) of CD4
13) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.24 Pain Relevance 0
A summary of all the measurements of PMA-induced CD4 degradation represented as the percent of undegraded CD4 remaining after 6 hours of PMA treatment is shown in Fig. 5B.
Protein_catabolism (degradation) of CD4
14) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.36 Pain Relevance 0
Pulse labeled CD4 has been shown to proceed to the cell surface via the secretory pathway within 30–60 minutes after synthesis, internalize via endocytosis, and undergo degradation in lysosomes [34].
Protein_catabolism (degradation) of CD4
15) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.30 Pain Relevance 0
Taken together, these findings suggest that PMA-induced CD4 degradation may be partially dependent on TSG101 and Vps4 function and only during early times after exposure to PMA.
Protein_catabolism (degradation) of CD4
16) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.16 Pain Relevance 0
At early time points, CD4 degradation was slightly attenuated, but by 6 h, Vps4E228Q-GFP expressing cells had degraded CD4 as efficiently as cells expressing GFP (Fig. 4C).
Protein_catabolism (degradation) of CD4
17) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.11 Pain Relevance 0
With prolonged PMA treatment, CD4 degradation can proceed in the absence of functional TSG101 and Vps4.


Protein_catabolism (degradation) of CD4
18) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.18 Pain Relevance 0
In contrast, lysosomal inhibitors (ammonium chloride and chloroquine) clearly inhibited CD4 degradation (Fig. 5B).
Protein_catabolism (degradation) of CD4
19) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.35 Pain Relevance 0
At early time points, CD4 degradation was slightly attenuated in TSG101 depleted cells (Fig. 4B, 2 hour time point).
Protein_catabolism (degradation) of CD4
20) Confidence 0.35 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0

General Comments

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