INT226647

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.31
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
B lymphocytes 4
lungs 2
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 83.92 Quite High
antagonist 1 65.84 Quite High
Pain 5 55.96 Quite High
Inflammation 2 16.60 Low Low
imagery 7 12.52 Low Low
chemokine 9 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 99.84 Very High Very High Very High
Lymphatic System Cancer 72 99.04 Very High Very High Very High
Metastasis 106 98.84 Very High Very High Very High
Cancer 130 95.92 Very High Very High Very High
Macroglobulinemia 28 93.16 High High
Breast Cancer 34 88.80 High High
Targeted Disruption 1 86.88 High High
Apoptosis 10 83.60 Quite High
Peripheral Arterial Disease 5 80.96 Quite High
Hypoxia 78 68.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, CXCR4 expression on B lymphocytes was found to be down-regulated when compared to other NHL types (p < 0.001).
Negative_regulation (down) of Gene_expression (expression) of CXCR4 in B lymphocytes associated with lymphatic system cancer
1) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.57 Pain Relevance 0.06
In fact, CXCR4 expression on B lymphocytes was found to be down-regulated when compared to other NHL types (p < 0.001).
Negative_regulation (regulated) of Gene_expression (expression) of CXCR4 in B lymphocytes associated with lymphatic system cancer
2) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.57 Pain Relevance 0.06
Migration of HSC is not prevented by blocking the SDF-1/CXCR4-axis
Negative_regulation (blocking) of Gene_expression (/) of CXCR4
3) Confidence 0.35 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.07 Pain Relevance 0
knockdown in MDA-MB-231 cells decreased CXCR4 expression in vitro and inhibited bone metastasis in vivo, with no difference in metastasis to other organs, such as the lungs or adrenal glands.
Negative_regulation (decreased) of Gene_expression (expression) of CXCR4 in lungs associated with metastasis
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.50 Pain Relevance 0.03
These receptors could, in the long run, contribute to maintaining or replenishing the cell surface levels of CXCR4 in HIV-1 infected cells.
Negative_regulation (replenishing) of Gene_expression (levels) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.60 Pain Relevance 0.16

General Comments

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