INT226649

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.83
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 8 95.60 Very High Very High Very High
Multiple sclerosis 1 79.80 Quite High
Inflammation 11 77.60 Quite High
Kinase C 8 71.92 Quite High
Central nervous system 1 50.40 Quite High
imagery 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 155 99.12 Very High Very High Very High
Metastasis 212 98.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 97.04 Very High Very High Very High
Apoptosis 19 89.88 High High
Demyelinating Disease 1 79.80 Quite High
Multiple Sclerosis 1 78.68 Quite High
INFLAMMATION 23 77.60 Quite High
Cytomegalovirus Infection 2 76.80 Quite High
Breast Cancer 68 76.52 Quite High
Shock 1 74.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
additively increase prometastatic factors VEGF and CXCR4
Positive_regulation (factors) of Positive_regulation (increase) of CXCR4
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.85 Pain Relevance 0
Combined treatment additively increased VEGF and CXCR4 promoter activation.
Positive_regulation (increased) of Positive_regulation (activation) of CXCR4
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.53 Pain Relevance 0
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Positive_regulation (levels) of Cxcr4
3) Confidence 0.38 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
We speculate that during the late stages of the viral life cycle when mostly structural proteins such as Gag are expressed, SDF-1 induced CXCR4 downregulation is attenuated resulting in the accumulation of densensitized CXCR4 within intracellular compartments.
Positive_regulation (resulting) of Positive_regulation (accumulation) of CXCR4
4) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.68 Pain Relevance 0.14
Thus, accumulation of intracellular HA-CXCR4 did not result in altered SDF-1 induced CXCR4 signaling in Gag expressing cells.


Neg (not) Positive_regulation (result) of Positive_regulation (induced) of CXCR4
5) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.46 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox