INT22665

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Context Info
Confidence 0.31
First Reported 1990
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP10) extracellular space (MMP10) extracellular region (MMP10)
proteinaceous extracellular matrix (MMP10)
MMP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 3 98.66 Very High Very High Very High
Osteoarthritis 1 75.00 Quite High
metalloproteinase 4 50.00 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 1 75.00 Quite High
INFLAMMATION 1 75.00 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Rotator Cuff Tears 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro paracetamol had no effect on metalloprotease whereas TA induced a significant inhibition of stromelysin.
Negative_regulation (inhibition) of stromelysin associated with paracetamol
1) Confidence 0.31 Published 1990 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 2315705 Disease Relevance 0.15 Pain Relevance 0.31
Reverse transcription polymerase chain reaction was performed for the collagenases (MMP-1, MMP-8, MMP-13), the stromelysins (MMP-3, MMP-10, MMP-11), and the tissue inhibitors of metalloproteinase (TIMP-1, TIMP-2, TIMP-3, TIMP-4).
Negative_regulation (inhibitors) of MMP-10
2) Confidence 0.01 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0

General Comments

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