INT22665

Context Info Confidence 0.31 First Reported 1990 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.15 Pain Relevance 0.31

peptidase activity (MMP10) extracellular space (MMP10) extracellular region (MMP10) proteinaceous extracellular matrix (MMP10)

MMP10 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 3 98.66 Osteoarthritis 1 75.00 metalloproteinase 4 50.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 1 75.00 INFLAMMATION 1 75.00 Pain 1 5.00 Rotator Cuff Tears 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In vitro paracetamol had no effect on metalloprotease whereas TA induced a significant inhibition of stromelysin.

Negative_regulation (inhibition) of stromelysin associated with paracetamol

1) Confidence 0.31 Published 1990 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 2315705 Disease Relevance 0.15 Pain Relevance 0.31

Reverse transcription polymerase chain reaction was performed for the collagenases (MMP-1, MMP-8, MMP-13), the stromelysins (MMP-3, MMP-10, MMP-11), and the tissue inhibitors of metalloproteinase (TIMP-1, TIMP-2, TIMP-3, TIMP-4).

Negative_regulation (inhibitors) of MMP-10

2) Confidence 0.01 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0

General Comments

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