INT226651

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 23
Disease Relevance 4.92
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hgs) endosome (Hgs) transport (Hgs)
kinase activity (Hgs) cytoplasm (Hgs)
Anatomy Link Frequency
monocytes 2
nucleus 2
meshwork 2
Hgs (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 75 98.98 Very High Very High Very High
rheumatoid arthritis 56 97.24 Very High Very High Very High
Inflammation 93 94.08 High High
cytokine 46 93.04 High High
spinal inflammation 21 78.72 Quite High
antagonist 21 60.00 Quite High
Arthritis 9 31.44 Quite Low
Central nervous system 21 5.00 Very Low Very Low Very Low
agonist 21 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 99.60 Very High Very High Very High
Death 22 98.88 Very High Very High Very High
Cardiovascular Disease 21 97.36 Very High Very High Very High
Rheumatoid Arthritis 56 97.24 Very High Very High Very High
Disease 213 96.24 Very High Very High Very High
Asthma 63 95.12 Very High Very High Very High
INFLAMMATION 94 94.08 High High
Inflammatory Bowel Disease 42 84.56 Quite High
Systemic Lupus Erythematosus 21 81.72 Quite High
Leukemia 42 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transient overexpression of hGR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of hGR
1) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0.12
Increased expression of hGR?
Positive_regulation (Increased) of Gene_expression (expression) of hGR
2) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.26 Pain Relevance 0.04
Overexpression of hGR?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of hGR
3) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.10 Pain Relevance 0.13
translocates to the nucleus more slowly in response to glucocorticoid treatment (an effect also seen after overexpression of hGR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of hGR in nucleus
4) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.25 Pain Relevance 0.04
Finally, a correlation has been found between increased expression of hGR?
Positive_regulation (increased) of Gene_expression (expression) of hGR
5) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 1.18 Pain Relevance 0.08
Increasing the expression of hGR?
Positive_regulation (Increasing) of Gene_expression (expression) of hGR
6) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0.14
An increased expression of hGR?
Positive_regulation (increased) of Gene_expression (expression) of hGR
7) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.49 Pain Relevance 0.03
This polymorphism is therefore considered to increase the expression of hGR?
Positive_regulation (increase) of Gene_expression (expression) of hGR
8) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.81 Pain Relevance 0.13
Increased expression of hGR?
Positive_regulation (Increased) of Gene_expression (expression) of hGR
9) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0.09
In cells derived from human eye tissue (trabecular meshwork cells), overexpression of hGR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of hGR in meshwork
10) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.13
It has been suggested that, at equivalent doses, the effects of triamcinolone and dexamethasone, but not of methylprednisolone, are suppressed by overexpression of the hGR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of hGR associated with dexamethasone
11) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656252 Disease Relevance 0 Pain Relevance 0.05
Overexpression of hGR?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of hGR
12) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0.11
In vivo relevance; lessons from hGR?
Positive_regulation (lessons) of Gene_expression (lessons) of hGR
13) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.08 Pain Relevance 0
Overexpression of hGR?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of hGR
14) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.07
However, this difference is not observed at the protein level, at which a higher hGR?
Positive_regulation (higher) of Neg (not) Gene_expression (observed) of hGR
15) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.05 Pain Relevance 0.03
However, this difference is not observed at the protein level, at which a higher hGR?
Neg (not) Positive_regulation (observed) of Neg (not) Gene_expression (observed) of hGR
16) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.05 Pain Relevance 0.03
For example, human monocytes have significantly higher hGR?
Positive_regulation (have) of Gene_expression (have) of hGR in monocytes
17) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.15 Pain Relevance 0.04
The two divergence points are located in helix 11 of the LBD, resulting in an alternative ending of helix 11 and the absence of helix 12 for both hGR?
Positive_regulation (resulting) of Neg (absence) Gene_expression (absence) of hGR
18) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
First, stable overexpression of hGR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of hGR
19) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.05 Pain Relevance 0.03
Thus, relatively high expression levels of hGR?
Positive_regulation (levels) of Gene_expression (expression) of hGR
20) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.47 Pain Relevance 0.12

General Comments

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