INT226654

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 6 30.08 Quite Low
Inflammatory response 6 6.12 Low Low
Kinase C 24 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 450 99.86 Very High Very High Very High
Infection 60 94.00 High High
Cytomegalovirus Infection 6 47.16 Quite Low
INFLAMMATION 6 5.76 Low Low
Superinfection 24 5.00 Very Low Very Low Very Low
Apoptosis 24 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, experiments in Jurkat cells reveal that expression of HIV-1 Gag attenuates downregulation of endogenous CXCR4 in the presence of SDF-1, PMA and ionomycin.
Negative_regulation (attenuates) of Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.34 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.66 Pain Relevance 0
Consequently, the expression of HIV-1 Gag attenuated CXCR4 downregulation, while having little to no effect on CD4 downregulation.
Negative_regulation (attenuated) of Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.41 Pain Relevance 0
Incubation of Gag-GFP expressing Jurkat cells with SDF-1, PMA and ionomycin revealed that downregulation of endogenous CXCR4 was clearly attenuated by expression of wt Gag-GFP (Fig. 3C,D,E).
Negative_regulation (attenuated) of Negative_regulation (downregulation) of CXCR4
3) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.82 Pain Relevance 0
Our findings indicate that SDF-1-induced CXCR4 downregulation is defective when ESCRT-I function is impaired, while PMA-induced CD4 downregulation is not.
Negative_regulation (defective) of Negative_regulation (downregulation) of CXCR4
4) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.41 Pain Relevance 0
SDF-1-induced CXCR4 downregulation was sharply reduced when TSG101 function is inhibited, while PMA-induced CD4 downregulation was relatively unaffected.
Negative_regulation (reduced) of Negative_regulation (downregulation) of CXCR4
5) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.44 Pain Relevance 0
Expression of HIV-1 Gag attenuated downregulation of CXCR4, resulting in accumulation of undegraded receptors within intracellular compartments.
Negative_regulation (attenuated) of Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.25 Published 2008 Journal Virol J Section Abstract Doc Link PMC2262066 Disease Relevance 0.65 Pain Relevance 0

General Comments

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