INT226667

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 39
Disease Relevance 7.33
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hgs) endosome (Hgs) transport (Hgs)
kinase activity (Hgs) cytoplasm (Hgs)
Anatomy Link Frequency
monocytes 1
HeLa 1
U-2 OS 1
meshwork 1
nucleus 1
Hgs (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 132 98.98 Very High Very High Very High
cytokine 80 96.92 Very High Very High Very High
rheumatoid arthritis 106 96.72 Very High Very High Very High
antagonist 36 96.56 Very High Very High Very High
Inflammation 162 94.08 High High
spinal inflammation 36 88.16 High High
Arthritis 18 61.68 Quite High
Central nervous system 36 38.72 Quite Low
agonist 36 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 99.60 Very High Very High Very High
Death 38 98.88 Very High Very High Very High
Cardiovascular Disease 36 97.36 Very High Very High Very High
Rheumatoid Arthritis 106 96.72 Very High Very High Very High
Disease 366 96.24 Very High Very High Very High
Repression 144 95.56 Very High Very High Very High
Asthma 108 94.72 High High
INFLAMMATION 163 94.08 High High
Systemic Lupus Erythematosus 36 93.00 High High
Nasal Polyps 72 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cells derived from human eye tissue (trabecular meshwork cells), overexpression of hGR?
Gene_expression (overexpression) of hGR in meshwork
1) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.13
Thus, relatively high expression levels of hGR?
Gene_expression (expression) of hGR
2) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.47 Pain Relevance 0.12
This polymorphism is therefore considered to increase the expression of hGR?
Gene_expression (expression) of hGR
3) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.81 Pain Relevance 0.12
Overexpression of hGR?
Gene_expression (Overexpression) of hGR
4) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0.11
Finally, a correlation has been found between increased expression of hGR?
Gene_expression (expression) of hGR
5) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 1.18 Pain Relevance 0.08
translocates to the nucleus more slowly in response to glucocorticoid treatment (an effect also seen after overexpression of hGR?
Gene_expression (overexpression) of hGR in nucleus
6) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.25 Pain Relevance 0.04
expression is significantly lower than the expression of hGR?
Gene_expression (expression) of hGR
7) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.11 Pain Relevance 0.03
Increased expression of hGR?
Gene_expression (expression) of hGR
8) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.26 Pain Relevance 0.04
Increased expression of hGR?
Gene_expression (expression) of hGR
9) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0.09
Overexpression of hGR?
Gene_expression (Overexpression) of hGR
10) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.10 Pain Relevance 0.13
It has been suggested that, at equivalent doses, the effects of triamcinolone and dexamethasone, but not of methylprednisolone, are suppressed by overexpression of the hGR?
Gene_expression (overexpression) of hGR associated with dexamethasone
11) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656252 Disease Relevance 0 Pain Relevance 0.05
An increased expression of hGR?
Gene_expression (expression) of hGR
12) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.49 Pain Relevance 0.03
Increasing the expression of hGR?
Gene_expression (expression) of hGR
13) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0.14
Transient overexpression of hGR?
Gene_expression (overexpression) of hGR
14) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0.12
Overexpression of hGR?
Gene_expression (Overexpression) of hGR
15) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.07
tr [Gervois et al., 1999], and overexpression of TIF2/GRIP1 attenuates the suppressive effect of hGR?
Gene_expression (effect) of hGR
16) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
Of the splice variants that occur in humans and rodents, only hGR?
Gene_expression (only) of hGR
17) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
For example, human monocytes have significantly higher hGR?
Gene_expression (have) of hGR in monocytes
18) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.15 Pain Relevance 0.04
The two divergence points are located in helix 11 of the LBD, resulting in an alternative ending of helix 11 and the absence of helix 12 for both hGR?
Neg (absence) Gene_expression (absence) of hGR
19) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
A single-nucleotide polymorphism in the glucocorticoid receptor gene in the region encoding the 3Â’UTR of hGR?
Gene_expression (encoding) of hGR
20) Confidence 0.65 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 1.01 Pain Relevance 0.13

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