INT226670

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 14
Disease Relevance 2.07
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hgs) endosome (Hgs) transport (Hgs)
kinase activity (Hgs) cytoplasm (Hgs)
Anatomy Link Frequency
monocytes 1
Hgs (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 99.44 Very High Very High Very High
Inflammation 48 97.84 Very High Very High Very High
antagonist 12 97.84 Very High Very High Very High
cytokine 24 96.72 Very High Very High Very High
rheumatoid arthritis 12 47.40 Quite Low
dexamethasone 36 37.40 Quite Low
spinal inflammation 12 27.04 Quite Low
Central nervous system 12 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 50 97.84 Very High Very High Very High
Stress 12 94.28 High High
Repression 48 93.12 High High
Disease 120 92.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 81.20 Quite High
Cardiovascular Disease 12 73.84 Quite High
Asthma 36 70.48 Quite High
Nasal Polyps 24 59.36 Quite High
Inflammatory Bowel Disease 24 53.04 Quite High
Colon Cancer 24 48.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a large number of studies, increased hGR?
Positive_regulation (increased) of hGR
1) Confidence 0.67 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.39 Pain Relevance 0.03
Thus, although limited data are available, a role for hGR?
Positive_regulation (role) of hGR
2) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0.09
Second, stable overexpression of green fluorescent protein (GFP)-tagged hGR?
Positive_regulation (tagged) of hGR
3) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
Experiments concerning the expression levels of hGR?
Positive_regulation (levels) of hGR
4) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
However, this difference is not observed at the protein level, at which a higher hGR?
Positive_regulation (higher) of hGR
5) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.05 Pain Relevance 0.03
, which leads to the generation of a mRNA encoding hGR?
Positive_regulation (generation) of hGR
6) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.14 Pain Relevance 0.04
In 1985, two human GR (hGR) isoforms were identified and named hGR?
Positive_regulation (named) of hGR
7) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.19 Pain Relevance 0.05
In 1985, two human GR (hGR) isoforms were identified and named hGR?
Positive_regulation (named) of hGR
8) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.19 Pain Relevance 0.05
For example, human monocytes have significantly higher hGR?
Positive_regulation (higher) of hGR in monocytes
9) Confidence 0.49 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.14 Pain Relevance 0.04
However, in none of the studies mentioned here, has it been demonstrated whether the decrease in sensitivity is due to the increased hGR?
Spec (whether) Positive_regulation (increased) of hGR
10) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.17 Pain Relevance 0.05
-isoform may alter gene transcription independent from the canonical receptor and increased hGR?
Positive_regulation (increased) of hGR
11) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2716050 Disease Relevance 0.09 Pain Relevance 0
Addition of RU486 increased the fraction of hGR?
Positive_regulation (increased) of hGR
12) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.16 Pain Relevance 0.05
Another recent study showed that lysosomal sorting of the GPCR, PAR-1 (Protease-activated receptor-1) does not require Hrs or TSG101 [39].
Neg (not) Positive_regulation (require) of Hrs
13) Confidence 0.07 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.21 Pain Relevance 0.09
For example, sorting and lysosomal degradation of the Delta Opioid Receptor (DOR), a GPCR, is Hrs and Vps4 dependent but does not require TSG101 (ESCRT-I) [21].
Positive_regulation (dependent) of Hrs associated with opioid
14) Confidence 0.03 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.24 Pain Relevance 0.10

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