INT226675

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.02
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 12 72.44 Quite High
imagery 6 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 225 99.44 Very High Very High Very High
Infection 30 92.72 High High
Superinfection 12 80.16 Quite High
Apoptosis 12 66.48 Quite High
Cancer 9 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore predict that lysosomal degradation of CD4 should not be impeded by Gag in an HIV-1 infected cell.
Neg (not) Negative_regulation (impeded) of Protein_catabolism (degradation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.31 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.67 Pain Relevance 0.14
At early time points, CD4 degradation was slightly attenuated in TSG101 depleted cells (Fig. 4B, 2 hour time point).
Negative_regulation (attenuated) of Protein_catabolism (degradation) of CD4
2) Confidence 0.23 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0
In contrast, lysosomal inhibitors (ammonium chloride and chloroquine) clearly inhibited CD4 degradation (Fig. 5B).
Negative_regulation (inhibited) of Protein_catabolism (degradation) of CD4
3) Confidence 0.23 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.35 Pain Relevance 0

General Comments

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