INT226677

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 100.00 Very High Very High Very High
Macroglobulinemia 14 99.44 Very High Very High Very High
Lymphatic System Cancer 36 99.04 Very High Very High Very High
Infection 20 98.64 Very High Very High Very High
Chronic Lymphoid Leukemia 7 96.00 Very High Very High Very High
Cytomegalovirus Infection 2 80.92 Quite High
Disease 5 48.96 Quite Low
Superinfection 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In WM, we observed a significant CXCR4 down-regulation in comparison to other NHL types (Figure 1).
Regulation (regulation) of Negative_regulation (down) of CXCR4 associated with macroglobulinemia and lymphatic system cancer
1) Confidence 0.25 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 1.25 Pain Relevance 0
Therefore, studying the effects of HIV-1 Gag expression on CXCR4 downregulation kinetics in these cells should provide insight into the physiologic processes occurring during HIV-1 infection.
Regulation (effects) of Negative_regulation (downregulation) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection and infection
2) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.95 Pain Relevance 0
SDF-1 induced CXCR4 downregulation is ESCRT-I dependent
Regulation (dependent) of Negative_regulation (downregulation) of CXCR4
3) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.34 Pain Relevance 0

General Comments

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