INT226681

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.01
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tsg101) endosome (Tsg101) transport (Tsg101)
cytoplasm (Tsg101) protein modification process (Tsg101) nucleolus (Tsg101)
Tsg101 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 16 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 300 99.00 Very High Very High Very High
Cancer 12 83.56 Quite High
Infection 40 55.20 Quite High
Superinfection 16 27.44 Quite Low
Apoptosis 16 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of full length TSG101 has been shown to inhibit ESCRT-I function and block EGF-induced EGFR downregulation [14,32].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of TSG101
1) Confidence 0.30 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.14 Pain Relevance 0
For TSG101 knockdown experiments, COS-1 cells were seeded to approximately 30% density and transfected the next day with 25 to 50 nM TSG101 or LacZ siRNA and 0.5 to 1 ?
Positive_regulation (transfected) of Gene_expression (transfected) of TSG101
2) Confidence 0.21 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.19 Pain Relevance 0
Given that HIV-1 Gag competes with Hrs for TSG101 in vitro [48], and that overexpression of TSG101-binding regions of Hrs inhibits HIV-1 release [49], we hypothesized that expression of Gag would compete for TSG101 binding and function in vivo.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TSG101-binding associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.21 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.46 Pain Relevance 0
COS-1 cells overexpressing TSG101 also exhibited attenuated HA-CXCR4 degradation (Fig. 1A).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TSG101
4) Confidence 0.20 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.21 Pain Relevance 0

General Comments

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