INT226689

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tsg101) endosome (Tsg101) transport (Tsg101)
cytoplasm (Tsg101) protein modification process (Tsg101) nucleolus (Tsg101)
Tsg101 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 4 90.32 High High
Glutamate 6 62.64 Quite High
agonist 18 5.00 Very Low Very Low Very Low
antidepressant 10 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 98.60 Very High Very High Very High
Neurological Disease 4 69.96 Quite High
Cancer 6 66.04 Quite High
Toxicity 1 61.84 Quite High
Apoptosis 24 58.24 Quite High
Injury 2 53.92 Quite High
Superinfection 8 36.72 Quite Low
Neurodegenerative Disease 3 35.36 Quite Low
Motor Neuron Diseases 1 29.28 Quite Low
Disease 2 24.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, HIV-1 recruits ESCRT complexes to sites of viral assembly through direct interactions between the Gag polyprotein and two cellular ESCRT proteins: TSG101 and AIP1/Alix [6-9].
TSG101 Binding (interactions) of associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.33 Pain Relevance 0
Given that HIV-1 Gag competes with Hrs for TSG101 in vitro [48], and that overexpression of TSG101-binding regions of Hrs inhibits HIV-1 release [49], we hypothesized that expression of Gag would compete for TSG101 binding and function in vivo.
TSG101 Binding (binding) of associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.53 Pain Relevance 0
Structurally, the extracellular domain of Trk receptors consists of a cysteine-rich cluster (CC1), followed by three leucine-rich repeats, another CC2 and two immunoglobulin (Ig)-like domains, which are involved in ligand binding.
CC2 Binding (binding) of
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.24 Pain Relevance 0.16

General Comments

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