INT226697

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tsg101) endosome (Tsg101) transport (Tsg101)
cytoplasm (Tsg101) protein modification process (Tsg101) nucleolus (Tsg101)
Anatomy Link Frequency
vesicles 1
Tsg101 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 6 32.80 Quite Low
Kinase C 20 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 376 97.84 Very High Very High Very High
Targeted Disruption 1 90.56 High High
Cancer 16 61.96 Quite High
Superinfection 20 43.44 Quite Low
Infection 53 5.00 Very Low Very Low Very Low
Apoptosis 20 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 5 5.00 Very Low Very Low Very Low
Bacillus Anthracis Infection 3 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, depletion of TSG101 and other ESCRT components inhibits lysosomal downregulation of ligand-activated growth factor receptors, such as the EGF Receptor (EGFR) [11-13].
Negative_regulation (depletion) of TSG101
1) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.39 Pain Relevance 0
Our observations that TSG101/ESCRT-I dependent downregulation of CXCR4 (Figs 2, 3) and EGFR [14] are attenuated in HIV-1 Gag expressing cells indicate that Gag functionally depletes the ESCRT complexes, thereby interrupting other ESCRT-dependent pathways in the cell.
Negative_regulation (downregulation) of TSG101 associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.55 Pain Relevance 0
In order to determine whether SDF-1 induced HA-CXCR4 downregulation is dependent on the ESCRT-I complex, cells were depleted of the critical ESCRT-I component, TSG101.
Negative_regulation (depleted) of TSG101
3) Confidence 0.18 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0
Depletion of TSG101 or introduction of dominant negative mutants of AIP1/Alix arrests HIV-1 budding at a late stage and blocks viral particle release [7,10].
Negative_regulation (Depletion) of TSG101 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.38 Pain Relevance 0
SDF-1-induced CXCR4 downregulation was sharply reduced when TSG101 function is inhibited, while PMA-induced CD4 downregulation was relatively unaffected.
Negative_regulation (inhibited) of TSG101
5) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.43 Pain Relevance 0
Knockdown of Tsg101, an ESCRT-I subunit, causes pleiotropic changes in early endosome morphology, including tubulation, reduction in the number of lumenal vesicles [20], and perhaps, the formation of a mammalian equivalent of the yeast Class E compartment [31].
Negative_regulation (Knockdown) of Tsg101 in vesicles
6) Confidence 0.03 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2528051 Disease Relevance 0.16 Pain Relevance 0

General Comments

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