INT226698

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.06
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T-cell 4
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 8 99.74 Very High Very High Very High
tolerance 1 87.68 High High
Arthritis 68 85.52 High High
rheumatoid arthritis 10 81.68 Quite High
Inflammation 6 66.40 Quite High
cytokine 5 63.20 Quite High
Inflammatory response 2 56.12 Quite High
chemokine 2 50.36 Quite High
imagery 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 13 99.56 Very High Very High Very High
Sprains And Strains 4 97.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 90.44 High High
Juvenile Chronic Polyarthritis 67 85.52 High High
Hematological Disease 18 85.28 High High
Rheumatoid Arthritis 10 81.68 Quite High
Apoptosis 46 73.44 Quite High
INFLAMMATION 8 66.40 Quite High
Recurrence 6 47.84 Quite Low
Infection 20 32.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using triple transgenic mice, we are able to simulate the functional interaction between human CD4 and human MHC-II molecules.
Positive_regulation (simulate) of CD4 Binding (interaction) of associated with targeted disruption
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.57 Pain Relevance 0.04
PKC is normally activated upon binding of antigen to the T-cell receptor and its associated CD4 [58].
Positive_regulation (activated) of CD4 Binding (associated) of in T-cell associated with kinase c
2) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.52 Pain Relevance 0.20
Antigens, mitogens and PKC modulators such as PMA induce internalization of CD4, thereby regulating its cell surface expression [22,23].
Positive_regulation (induce) of CD4 Binding (internalization) of
3) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.23 Pain Relevance 0.05
In the rheumatoid joint enriched with DCs, interaction of DCs and CD4+ T cells can therefore be highly augmented.
Positive_regulation (augmented) of CD4 Binding (interaction) of in T cells
4) Confidence 0.20 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778712 Disease Relevance 0.74 Pain Relevance 0.34

General Comments

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