INT226712

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.34
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) endoplasmic reticulum (Sdf2l1) signal transducer activity (Cxcr4)
signal transduction (Cxcr4) plasma membrane (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
Anatomy Link Frequency
T cells 2
Sdf2l1 (Mus musculus)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 8 66.56 Quite High
imagery 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 99.64 Very High Very High Very High
Apoptosis 8 91.84 High High
Cytomegalovirus Infection 2 85.28 High High
Superinfection 8 50.92 Quite High
Infection 20 50.32 Quite High
Cancer 6 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We speculate that during the late stages of the viral life cycle when mostly structural proteins such as Gag are expressed, SDF-1 induced CXCR4 downregulation is attenuated resulting in the accumulation of densensitized CXCR4 within intracellular compartments.
SDF-1 Positive_regulation (induced) of Negative_regulation (downregulation) of CXCR4
1) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.75 Pain Relevance 0.13
HIV-1 Gag attenuates SDF-1 induced downregulation of endogenous CXCR4 in Jurkat T cells
SDF-1 Positive_regulation (induced) of Negative_regulation (downregulation) of CXCR4 in T cells associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.60 Pain Relevance 0

General Comments

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