INT226716

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 1.42
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) endoplasmic reticulum (Sdf2l1) signal transducer activity (Cxcr4)
signal transduction (Cxcr4) plasma membrane (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
Anatomy Link Frequency
kidney 3
HSC 2
leukocytes 1
tail vein 1
Cxcr4 (Mus musculus)
Sdf2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 13 100.00 Very High Very High Very High
Inflammatory response 1 96.48 Very High Very High Very High
ischemia 24 84.80 Quite High
Inflammation 12 55.72 Quite High
imagery 14 51.64 Quite High
Versed 12 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 13 96.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 92.24 High High
Hypoxia 6 87.52 High High
Cv Unclassified Under Development 24 84.80 Quite High
Injury 150 77.24 Quite High
Acute Renal Failure 18 5.00 Very Low Very Low Very Low
Thrombosis 12 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unexpectedly, neutralization of endogenous SDF-1 or HSC-associated CXCR4 did not result in a significantly decreased migration of exogenous HSC to the ischemic injured or contralateral kidney (Figure 1C).
CXCR4 Binding (associated) of SDF-1 in kidney
1) Confidence 0.30 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.06 Pain Relevance 0
To validate whether anti-SDF-1 and anti-CXCR4 were also able to inhibit the migration of HSC in vivo, HSC were injected into the tail vein of naive mice with or without blocking either endogenous SDF-1 or HSC-associated CXCR4 with a monoclonal antibody as previously described [11,13,18,21].
CXCR4 Binding (associated) of SDF-1 in tail vein
2) Confidence 0.30 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.21 Pain Relevance 0.05
In conclusion, our initial hypothesis that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney is not supported by the results in this report.
CXCR4 Binding (interactions) of SDF-1 in kidney
3) Confidence 0.28 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.19 Pain Relevance 0.04
In conclusion, our initial hypothesis that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney is not supported by the results in this report.
CXCR4 Binding (interactions) of SDF-1 in kidney
4) Confidence 0.28 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.19 Pain Relevance 0.04
Therefore, we hypothesized that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney.
CXCR4 Binding (interactions) of SDF-1 in HSC
5) Confidence 0.28 Published 2009 Journal Nephrology Dialysis Transplantation Section Abstract Doc Link PMC2698094 Disease Relevance 0.14 Pain Relevance 0.04
Therefore, we hypothesized that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney.
CXCR4 Binding (interactions) of SDF-1 in HSC
6) Confidence 0.28 Published 2009 Journal Nephrology Dialysis Transplantation Section Abstract Doc Link PMC2698094 Disease Relevance 0.14 Pain Relevance 0.04
The ligand for CXCR4 is the chemokine stromal cell-derived factor (SDF-1), which regulates the movement of leukocytes during their development, homeostasis and inflammatory response [18].
CXCR4 Binding (ligand) of SDF-1 in leukocytes associated with chemokine and inflammatory response
7) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.48 Pain Relevance 0.10

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