INT226723

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) endoplasmic reticulum (Sdf2l1) signal transducer activity (Cxcr4)
signal transduction (Cxcr4) plasma membrane (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
Sdf2l1 (Mus musculus)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 16 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 300 95.08 Very High Very High Very High
Infection 40 92.60 High High
Cytomegalovirus Infection 4 66.88 Quite High
Superinfection 16 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, cells that were incubated in the presence of SDF-1 clearly exhibited a loss in receptor signal, confirming that SDF-1 induces degradation of HA-CXCR4.
SDF-1 Positive_regulation (induces) of Protein_catabolism (degradation) of CXCR4
1) Confidence 0.03 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.05 Pain Relevance 0
These data are similar to those reported in Figure 2, for SDF-I induced HA-CXCR4 degradation.


SDF-I Positive_regulation (induced) of Protein_catabolism (degradation) of CXCR4
2) Confidence 0.03 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.54 Pain Relevance 0
Indeed, in order to observe SDF-1 induced CXCR4 degradation in Jurkat cells, we needed to inhibit the synthesis of new receptors continuously with cycloheximide and incubate the cells with SDF-1, PMA and ionomycin (Fig. 3A).
SDF-1 Positive_regulation (induced) of Protein_catabolism (degradation) of CXCR4
3) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 1.01 Pain Relevance 0
Previous studies have established that SDF-1 induces internalization, endosomal trafficking and lysosomal degradation of CXCR4 and HA-tagged CXCR4 in a variety of cell types [19,20,30].
SDF-1 Positive_regulation (induces) of Protein_catabolism (degradation) of CXCR4
4) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.33 Pain Relevance 0

General Comments

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