INT226739

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tsg101, Cxcr4) plasma membrane (Tsg101, Cxcr4) cell differentiation (Tsg101)
transport (Tsg101) signal transducer activity (Cxcr4) cytoplasm (Tsg101)
Tsg101 (Mus musculus)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 98.96 Very High Very High Very High
Superinfection 8 18.80 Low Low
Infection 20 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data (Figs 1, 2) strongly suggest that SDF-1 induced CXCR4 downregulation is TSG101 and ESCRT-I dependent.
TSG101 Regulation (dependent) of Negative_regulation (downregulation) of CXCR4
1) Confidence 0.13 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.39 Pain Relevance 0
To study the role of TSG101 in CXCR4 downregulation, we used transfected COS-1 cells co-expressing GFP and HA-tagged CXCR4.
TSG101 Regulation (role) of Negative_regulation (downregulation) of CXCR4
2) Confidence 0.08 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.30 Pain Relevance 0

General Comments

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