INT22674

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 1990
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.65
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1, PLAT) extracellular region (SERPINE1, PLAT) peptidase activity (PLAT)
protein modification process (PLAT) plasma membrane (SERPINE1) cytoplasm (PLAT)
Anatomy Link Frequency
plasma 3
7D4 1
SERPINE1 (Homo sapiens)
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 99.60 Very High Very High Very High
Angina 16 99.40 Very High Very High Very High
metalloproteinase 6 82.16 Quite High
Inflammation 11 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.60 Very High Very High Very High
Cv General 3 Under Development 15 99.40 Very High Very High Very High
Atherosclerosis 14 80.68 Quite High
Rupture 6 61.68 Quite High
Coronary Heart Disease 10 51.44 Quite High
Acute Coronary Syndrome 35 50.00 Quite Low
Ventricular Remodeling 1 34.48 Quite Low
Thrombosis 4 33.00 Quite Low
Myocardial Infarction 15 30.80 Quite Low
Injury 3 29.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tissue plasminogen activator and PAI-1 may partly reflect their mutual association with the inflammatory response.
PAI-1 Binding (association) of Tissue plasminogen activator associated with inflammatory response
1) Confidence 0.04 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.36 Pain Relevance 0.16
MA-7D4 was used previously as capture antibody in combination with MA-7F5 conjugated to horseradish peroxidase (7F5-HRP) to construct an ELISA which was 12 times more sensitive towards free PAI-1 as compared to PAI-1 in complex with human tissue-type plasminogen activator (t-PA) (Blood 71: 220-225, 1988).
PAI-1 Binding (complex) of t-PA in 7D4
2) Confidence 0.02 Published 1990 Journal Thromb. Res. Suppl. Section Abstract Doc Link 2315899 Disease Relevance 0 Pain Relevance 0
In plasma from 48 patients suffering from angina pectoris no statistical difference in PAI-1 activity, PAI-1 antigen or PAI-1/t-PA complex could be observed as compared to normal subjects.
PAI-1 Neg (no) Binding (activity) of t-PA in plasma associated with angina
3) Confidence 0.02 Published 1990 Journal Thromb. Res. Suppl. Section Abstract Doc Link 2315899 Disease Relevance 0.10 Pain Relevance 0.10
MA-15H12, as capture antibody, in combination with MA-12A4 corjugated to horseradish peroxidase (12A4-HRP) yielded an ELISA which was equally sensitive towards free PAI-1 and PAI-1/t-PA complex.
PAI-1 Binding (complex) of t-PA
4) Confidence 0.02 Published 1990 Journal Thromb. Res. Suppl. Section Abstract Doc Link 2315899 Disease Relevance 0 Pain Relevance 0
MA-15H12, as capture antibody, in combination with MA-12A4 corjugated to horseradish peroxidase (12A4-HRP) yielded an ELISA which was equally sensitive towards free PAI-1 and PAI-1/t-PA complex.
PAI-1 Binding (complex) of t-PA
5) Confidence 0.02 Published 1990 Journal Thromb. Res. Suppl. Section Abstract Doc Link 2315899 Disease Relevance 0 Pain Relevance 0
It was found that 44% to 60% of free PAI-1 antigen in normal plasma is active and that t-PA occurs mainly as t-PA/PAI-1 complexes.
PAI-1 Binding (complexes) of t-PA in plasma
6) Confidence 0.02 Published 1990 Journal Thromb. Res. Suppl. Section Abstract Doc Link 2315899 Disease Relevance 0.10 Pain Relevance 0.10
It was found that 44% to 60% of free PAI-1 antigen in normal plasma is active and that t-PA occurs mainly as t-PA/PAI-1 complexes.
PAI-1 Binding (complexes) of t-PA in plasma
7) Confidence 0.02 Published 1990 Journal Thromb. Res. Suppl. Section Abstract Doc Link 2315899 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox