INT226768

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 6.34
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
arm 2
Hdl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 47 98.08 Very High Very High Very High
Inflammatory response 4 88.36 High High
adenocard 2 48.48 Quite Low
cytokine 3 39.92 Quite Low
Inflammatory mediators 4 33.52 Quite Low
agonist 25 5.00 Very Low Very Low Very Low
Kinase C 9 5.00 Very Low Very Low Very Low
Somatostatin 9 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 403 100.00 Very High Very High Very High
Coronary Heart Disease 72 99.10 Very High Very High Very High
Metabolic Syndrome 81 98.60 Very High Very High Very High
Targeted Disruption 13 98.56 Very High Very High Very High
Sepsis 4 98.46 Very High Very High Very High
Infection 3 98.30 Very High Very High Very High
INFLAMMATION 56 98.08 Very High Very High Very High
Heart Rate Under Development 17 96.80 Very High Very High Very High
Pressure And Volume Under Development 56 95.68 Very High Very High Very High
Hypoalphalipoproteinemias 16 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the general population, lower-than-normal HDL-C levels are inversely correlated with CHD; the risk of a coronary event is thought to increase 2% for every 1% decrease in HDL.
Positive_regulation (increase) of Negative_regulation (decrease) of HDL associated with coronary heart disease and disorder of lipid metabolism
1) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.63 Pain Relevance 0
High PLTP activity might promote CETP activity, thus decreasing HDL levels in human plasma.
Spec (might) Positive_regulation (promote) of Negative_regulation (decreasing) of HDL in plasma associated with disorder of lipid metabolism
2) Confidence 0.07 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2793253 Disease Relevance 1.37 Pain Relevance 0.04
Increase in HDL and decrease in LDL and VLDL particle numbers were seen only in the PED arm.
Positive_regulation (Increase) of Negative_regulation (decrease) of HDL in arm associated with disorder of lipid metabolism
3) Confidence 0.03 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.24 Pain Relevance 0
In acute and chronic inflammation, infection, sepsis and MS, there is an impairment in lipid and lipoprotein metabolism, with an increase in TG, LDL and LBP and a marked decrease of HDL [40,41].
Positive_regulation (increase) of Negative_regulation (decrease) of HDL associated with inflammation, metabolic syndrome, disorder of lipid metabolism, sepsis and infection
4) Confidence 0.01 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2262079 Disease Relevance 2.10 Pain Relevance 0.15

General Comments

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