INT22679

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Context Info
Confidence 0.36
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 17.33
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
plasma 3
blood 2
femoral artery 1
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 23 100.00 Very High Very High Very High
Inflammatory response 7 99.60 Very High Very High Very High
Angina 31 98.16 Very High Very High Very High
ischemia 10 97.44 Very High Very High Very High
antagonist 2 93.44 High High
Inflammation 99 82.96 Quite High
depression 61 82.24 Quite High
Restless leg syndrome 4 80.68 Quite High
tolerance 11 73.56 Quite High
Somatostatin 4 72.80 Quite High
Disease Link Frequency Relevance Heat
Depression 103 100.00 Very High Very High Very High
Keloid Scars 24 100.00 Very High Very High Very High
Atherosclerosis 31 99.90 Very High Very High Very High
Coronary Artery Disease 34 99.76 Very High Very High Very High
Cancer 84 99.68 Very High Very High Very High
INFLAMMATION 111 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 46 99.16 Very High Very High Very High
Disease 300 98.80 Very High Very High Very High
Aggression 11 98.48 Very High Very High Very High
Nicotine Addiction 6 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fibrin formed from plasma collected during and immediately post CABG was associated with increased fibrinolytic capacity and enhanced binding of a) MMP-9, b) the low Mw protease triplet (described above), and c) PA (as putative 110-kDa tPA:PAI-1 complex).
PAI-1 Binding (binding) of in plasma associated with metalloproteinase
1) Confidence 0.36 Published 2001 Journal Inflammation Section Abstract Doc Link 11820459 Disease Relevance 0.24 Pain Relevance 0.17
Our case had homozigous PAI-1 4G/4G and heterozygote JAK2V617F polymorphisms.
PAI-1 Binding (homozigous) of
2) Confidence 0.36 Published 2009 Journal Thromb J Section Body Doc Link PMC2652439 Disease Relevance 1.21 Pain Relevance 0
Several international research groups have demonstrated that the protein content of uPA and PAI-1 in the tumor correlates with disease aggressiveness and has a strong prognostic impact on disease-free survival and overall survival in patients with primary breast cancer [1-6].
PAI-1 Binding (content) of associated with cancer, breast cancer, aggression and disease
3) Confidence 0.36 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.90 Pain Relevance 0
Measurement of plasminogen activator inhibitor 1 (PAI-1) in plasma with various monoclonal antibody-based enzyme-linked immunosorbent assays.
plasminogen activator inhibitor 1 Binding (Measurement) of in plasma
4) Confidence 0.32 Published 1990 Journal Thromb. Res. Suppl. Section Title Doc Link 2315899 Disease Relevance 0 Pain Relevance 0
Measurement of plasminogen activator inhibitor 1 (PAI-1) in plasma with various monoclonal antibody-based enzyme-linked immunosorbent assays.
PAI-1 Binding (Measurement) of in plasma
5) Confidence 0.32 Published 1990 Journal Thromb. Res. Suppl. Section Title Doc Link 2315899 Disease Relevance 0 Pain Relevance 0
MA-15H12, as capture antibody, in combination with MA-12A4 corjugated to horseradish peroxidase (12A4-HRP) yielded an ELISA which was equally sensitive towards free PAI-1 and PAI-1/t-PA complex.
PAI-1 Binding (complex) of
6) Confidence 0.31 Published 1990 Journal Thromb. Res. Suppl. Section Abstract Doc Link 2315899 Disease Relevance 0 Pain Relevance 0
Our study is the first to simultaneously evaluate the association between depressive symptoms and various adipokines (adiponectin, resistin, PAI-1 and RBP4) in general populations.
PAI-1 Binding (association) of associated with depression
7) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.39 Pain Relevance 0.24
Our South Indian isolate, 3K, was found to be aligning with the Western cagPAI sequences (Figure 3B).
cagPAI Binding (aligning) of
8) Confidence 0.19 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1925095 Disease Relevance 0.25 Pain Relevance 0.03
In combination with other ECM proteins found in our analysis, PAI-1 and uPA, the association with DFI and OS became even more significant (p < 0.001).
PAI-1 Binding (combination) of
9) Confidence 0.18 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499618 Disease Relevance 0.52 Pain Relevance 0.06
Factor VIIIc, von Willebrand factor (vWF), tPA and PAI-1 are reported to be associated with CHD.
PAI-1 Binding (associated) of associated with coronary artery disease
10) Confidence 0.16 Published 1997 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 9352376 Disease Relevance 1.20 Pain Relevance 0.14
Tissue plasminogen activator and PAI-1 may partly reflect their mutual association with the inflammatory response.
PAI-1 Binding (association) of associated with inflammatory response
11) Confidence 0.15 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.35 Pain Relevance 0.16
There is a negative correlation of testosterone levels with plasminogen activator inhibitor-1 (PAI-1) (Glueck et al 1993; Phillips 1993), which is a major prothrombotic factor and known to be associated with progression of atherosclerosis, as well as other prothrombotic factors fibrinogen, ?
PAI-1 Binding (associated) of associated with increased venous pressure under development
12) Confidence 0.14 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.60 Pain Relevance 0
There is a negative correlation of testosterone levels with plasminogen activator inhibitor-1 (PAI-1) (Glueck et al 1993; Phillips 1993), which is a major prothrombotic factor and known to be associated with progression of atherosclerosis, as well as other prothrombotic factors fibrinogen, ?
activator inhibitor-1 Binding (associated) of associated with increased venous pressure under development
13) Confidence 0.12 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.60 Pain Relevance 0
This article describes a young woman with Lemierre's syndrome who was found to carry several genetic polymorphisms: a single nucleotide polymorphism (SNP) in the TLR 5, and SNPs on the gene promoters coding for TF and PAI-1.


PAI-1 Binding (coding) of associated with syndrome
14) Confidence 0.08 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1538604 Disease Relevance 0.96 Pain Relevance 0.07
and plasminogen activator inhibitor-1 (PAI-1), a downstream molecule affected by HIF-1, in keloids has been well documented.36 In addition, treatment against HIF-1?
PAI-1 Binding (documented.36) of associated with keloid scars
15) Confidence 0.08 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.16 Pain Relevance 0.10
and plasminogen activator inhibitor-1 (PAI-1), a downstream molecule affected by HIF-1, in keloids has been well documented.36 In addition, treatment against HIF-1?
PAI-1 Binding (plasminogen) of associated with keloid scars
16) Confidence 0.08 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.09 Pain Relevance 0.07
and plasminogen activator inhibitor-1 (PAI-1), a downstream molecule affected by HIF-1, in keloids has been well documented.36 In addition, treatment against HIF-1?
activator inhibitor-1 Binding (documented.36) of associated with keloid scars
17) Confidence 0.07 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.17 Pain Relevance 0.10
and plasminogen activator inhibitor-1 (PAI-1), a downstream molecule affected by HIF-1, in keloids has been well documented.36 In addition, treatment against HIF-1?
activator inhibitor-1 Binding (plasminogen) of associated with keloid scars
18) Confidence 0.07 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.09 Pain Relevance 0.07
A supportive finding for this hypothesis is the fact that VEGF receptor 1 (FLT1) and PAI-1, both known Egr-1 responsive genes, are also increased in the presence of glucose and insulin.
PAI-1 Binding (receptor) of
19) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.93 Pain Relevance 0.03
For this reason, the possible usefulness of a treatment with PAI-1 (PAI = plasminogen activator inhibitor) or TGB-?
PAI-1 Binding (treatment) of
20) Confidence 0.05 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.42 Pain Relevance 0.17

General Comments

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