INT226826

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.52
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn1b)
Anatomy Link Frequency
ventricles 1
TEK 1
Scn1b (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 47 100.00 Very High Very High Very High
Congenital analgesia 3 51.36 Quite High
Pain 44 50.00 Quite Low
Action potential 31 5.00 Very Low Very Low Very Low
sodium channel 18 5.00 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
action potential duration 5 5.00 Very Low Very Low Very Low
Thoracotomy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 6 95.84 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 13 93.04 High High
Syndrome 4 78.32 Quite High
Hyperplasia 3 74.92 Quite High
Congenital Anomalies 4 65.00 Quite High
Pain 46 50.00 Quite Low
Targeted Disruption 16 50.00 Quite Low
Adhesions 2 44.92 Quite Low
Pheochromocytoma 1 44.48 Quite Low
Polio 3 33.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, ventricles of such mice showed altered expression levels of Scn3b, Scn1b and Scn5a mRNA.
Gene_expression (expression) of Scn1b in ventricles
1) Confidence 0.57 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.33 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of Scn-1b in TEK
2) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.07 Pain Relevance 0
HEK293A cells (QBiogene), cultured in DMEM supplemented with 5% FCS, were transiently transfected with plasmids expressing either WT or mutant Nav1.7 plus DsRed2 and/or SCN1B plus SCN2B plus EGFP using lipofectamine 2000.
Gene_expression (expressing) of SCN1B associated with nav1.7
3) Confidence 0.41 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0 Pain Relevance 0.22
Freshly isolated Sk-34 cells (before culture) primarily expressed mRNAs for c-met, Scn-1b, ?
Gene_expression (expressed) of Scn-1b
4) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.05 Pain Relevance 0
After the third cellular division, expression of c-met, Scn-1b, ?
Gene_expression (expression) of Scn-1b
5) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.06 Pain Relevance 0

General Comments

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