INT226827

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.24
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Met) plasma membrane (Met) kinase activity (Met)
cytoplasm (Met)
Met (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 4 75.56 Quite High
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 60 92.12 High High
Cancer 25 88.52 High High
Sprains And Strains 46 81.68 Quite High
Disease 9 79.76 Quite High
Malignant Neoplastic Disease 1 70.48 Quite High
Carcinoma 2 65.00 Quite High
Infection 94 63.16 Quite High
Adhesions 10 55.68 Quite High
Hyperplasia 1 52.64 Quite High
Myocardial Infarction 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
InlB locally activates its receptor, c-Met, and increases endocytosis of junctional components, including E-cadherin.
c-Met Binding (receptor) of
1) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2869327 Disease Relevance 0.14 Pain Relevance 0.04
These studies indicate that InlB can bind and activate the basolateral c-Met receptor leading to clathrin-mediated internalization of c-Met.
c-Met Binding (bind) of
2) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.17 Pain Relevance 0
Freshly isolated Sk-34 cells (before culture) primarily expressed mRNAs for c-met, Scn-1b, ?
c-met Binding (mRNAs) of
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.05 Pain Relevance 0
Additionally, the molecular deregulation of the tyrosine kinase receptor c-MET has been associated with enhanced transcript levels [7].
c-MET Binding (associated) of
4) Confidence 0.04 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.88 Pain Relevance 0

General Comments

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