INT226829

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.56
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra1b) plasma membrane (Adra1b) signal transducer activity (Adra1b)
Anatomy Link Frequency
brains 1
TEK 1
Adra1b (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 12 38.16 Quite Low
amygdala 2 37.52 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 11 99.48 Very High Very High Very High
Alzheimer's Dementia 14 87.12 High High
Vascular Disease 2 86.48 High High
Hyperplasia 1 78.08 Quite High
Urological Neuroanatomy 4 76.84 Quite High
Neurodegenerative Disease 44 69.20 Quite High
Disease 12 50.00 Quite Low
Cognitive Disorder 12 45.92 Quite Low
Amyloid Plaque 10 44.32 Quite Low
Aging 6 28.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of Cacn-1b in TEK
1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
In addition, there was no significant difference in the expression levels of major ganglio-N-tetraosyl gangliosides (GM1, GD1a, GD1b and GT1b) in the brains between double-Tg and age-matched WT mice (Figure 3a and Table 1).
Gene_expression (expression) of GD1b in brains
2) Confidence 0.01 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2948441 Disease Relevance 0.08 Pain Relevance 0
On the other hand, Oikawa et al. (2009) crossbred Tg mice expressing human APP having Swedish and London mutations with GM2-synthase-knockout mice in which GM1, GD1a, GD1b and GT1b were completely missing but GM3 and GD3 were abundantly expressed (Takamiya et al., 1996).
Gene_expression (expressed) of GD1b associated with targeted disruption
3) Confidence 0.00 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2948441 Disease Relevance 0.41 Pain Relevance 0

General Comments

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