INT226835

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.04
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh2) plasma membrane (Cdh2) protein complex (Cdh2)
Anatomy Link Frequency
cardiomyocytes 2
fibroblast 1
epithelial cell 1
intestine 1
p120 1
Cdh2 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 36 96.48 Very High Very High Very High
addiction 11 82.24 Quite High
Kinase C 30 5.00 Very Low Very Low Very Low
anesthesia 19 5.00 Very Low Very Low Very Low
imagery 17 5.00 Very Low Very Low Very Low
Mechanosensation 16 5.00 Very Low Very Low Very Low
Somatostatin 16 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 248 99.84 Very High Very High Very High
Coronary Artery Disease 8 99.84 Very High Very High Very High
Cancer 26 99.56 Very High Very High Very High
Adhesions 193 99.36 Very High Very High Very High
Cyst 128 98.52 Very High Very High Very High
Apoptosis 159 97.76 Very High Very High Very High
Arrhythmia Under Development 40 97.60 Very High Very High Very High
Disease 218 96.48 Very High Very High Very High
Targeted Disruption 177 95.72 Very High Very High Very High
Familial Adenomatous Polyposis 4 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Isolated GFP(+) CPCs were co-cultured with NRVMs and subsequently assayed for GFP and N-Cadherin expression which mediates adhesion in the intercalated discs at the termini of cardiomyocytes thereby serving as a mechanical anchor for myofibrils at cell-cell contacts [20].
Gene_expression (expression) of N-Cadherin in cardiomyocytes associated with adhesions
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.30 Pain Relevance 0
Indirect data generated by over-expression of a dominant-negative N-cadherin or targeting p120-catenin suggest an important role in intestinal homeostasis [14], [15].
Gene_expression (expression) of N-cadherin in p120
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.82 Pain Relevance 0.10
But as expression of a dominant negative N-cadherin also interferes with fibroblast growth factor receptor activation and mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signaling [45], [46], the precise role of E-cadherin in this context remained unclear.
Gene_expression (expression) of N-cadherin in fibroblast
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.31 Pain Relevance 0.03
Moreover, during progression of colorectal and other tumors a switch in cadherin expression from E-cadherin to N-cadherin is observed coinciding with the transition from an epithelial to a mesenchymal phenotype leading to an increase in the invasive capabilities of cancer cells [6] and inactivation of one E-cadherin allele enhances tumor initiation in mice carrying a mutated adenomatous polyposis coli (APC) gene [13].
Gene_expression (expression) of N-cadherin associated with cancer and familial adenomatous polyposis
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.89 Pain Relevance 0.13
The intercalated disc contains four different types of intercellular junctions, three of which have been linked to cardiac arrhythmia in human and animal models: gap junctions (with connexins forming channels for ion transfer), adherens junctions (with N-cadherin stabilizing gap junctions), and desmosomes (structural organization of the intercalated disc).
Gene_expression (stabilizing) of N-cadherin associated with arrhythmia under development
5) Confidence 0.15 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.76 Pain Relevance 0
Although the expression and localization of the adherens junction protein N-cadherin was unaffected (Fig. 7 B), the localization of the gap junction protein Connexin 43 (Cx43) was altered in KO cardiomyocytes 8 wk after induction (Fig. 7 C).
Gene_expression (expression) of N-cadherin in cardiomyocytes associated with targeted disruption
6) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.38 Pain Relevance 0
A mouse model expressing a dominant negative N-cadherin mutant in the mouse intestine resulted in an increase in epithelial apoptosis rates, increased migration of enterocytes along the crypt-villus axis and impaired cellular differentiation [14], [44].
Neg (negative) Gene_expression (expressing) of N-cadherin in intestine associated with apoptosis
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.34 Pain Relevance 0.04
However, a recent comprehensive set of studies unequivocally demonstrated that the desmosomal components desmoglein 2 (Dsg 2), desmocollin 2 (Dsc 2), desmoplakin and plakophilin-2 as well as the adherens junction components N-cadherin, cadherin-11, ?
Gene_expression (components) of N-cadherin
8) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
In addition, E-cadherin expression is reduced, resulting in compensatory expression of N-cadherin (N-cad).
Gene_expression (expression) of N-cadherin associated with coronary artery disease
9) Confidence 0.05 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.98 Pain Relevance 0
At 4 or 12 weeks after skeletal muscle stem cell engraftment, cells formed multinucleated, cross-striated myofibers that express fast skeletal myosin heavy chain, but not intercalated disk proteins N-cadherin or connexin-43 [13].
Neg (not) Gene_expression (express) of N-cadherin in muscle stem cell
10) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 2, abnormal adherens and desmosomal junctions were found in ADPKD: intracellular junctions were devoid of desmosomal cadherins and associated proteins, which were sequestered to the cytoplasmic pools, and adherens junctions appeared disrupted, accompanied by a great reduction of Ecadherin expression and partial compensatory expression of N-cadherin [68].
Spec (partial) Gene_expression (expression) of N-cadherin associated with polycystic kidney disease
11) Confidence 0.05 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.07 Pain Relevance 0
However, the expression of N-cadherin in place of E-cadherin in ADPKD cells was not sufficient to maintain epithelial cell-cell adhesion [37, 69].
Gene_expression (expression) of N-cadherin in epithelial cell associated with polycystic kidney disease and adhesions
12) Confidence 0.05 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.06 Pain Relevance 0
N-cadherin, but not K-cadherin, was overexpressed in ADPKD cells and formed a complex with beta-catenin.
Gene_expression (overexpressed) of N-cadherin associated with polycystic kidney disease
13) Confidence 0.05 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.04 Pain Relevance 0
This view seemed to be supported by immuno-localization studies, which showed that desmoplakin as a desmosomal marker and the myocardial adherens junction protein N-cadherin displayed mutually exclusive spatial distribution patterns (Angst et al. 1997; Gutstein et al. 2003).
Gene_expression (marker) of N-cadherin
14) Confidence 0.05 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
Putative markers of mature NP cells – such as cytokeratins 8, 18 and 19, snaptosomal-associated protein 25 (SNAP-25), cadherin-2 and sclerostin domain-containing protein 1 (SOSTDC1) – are all also expressed by notochordal-like cells, in many cases at higher levels (Minogue et al., 2010).
Gene_expression (expressed) of cadherin-2
15) Confidence 0.04 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.09 Pain Relevance 0

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