INT226868

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 14
Disease Relevance 17.13
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8)
cytoplasm (Map3k8)
Anatomy Link Frequency
adipose tissue 4
subcutaneous adipose tissue 2
Map3k8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 360 99.40 Very High Very High Very High
cytokine 518 97.28 Very High Very High Very High
Inflammatory stimuli 67 97.08 Very High Very High Very High
Inflammatory mediators 26 39.28 Quite Low
Kinase C 13 28.00 Quite Low
anesthesia 13 5.00 Very Low Very Low Very Low
tolerance 13 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 455 99.40 Very High Very High Very High
Obesity 1378 99.32 Very High Very High Very High
Diabetes Mellitus 104 98.40 Very High Very High Very High
Cancer 91 86.04 High High
Necrosis 40 75.00 Quite High
Overactive Bladder 18 71.16 Quite High
Disease 16 51.24 Quite High
Metabolic Disorder 13 48.24 Quite Low
Insulin Resistance 130 46.44 Quite Low
Targeted Disruption 13 35.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, inflammation linked to obesity could promote both the activation of Tpl2 that is coupled to its rapid degradation and the stimulation of Tpl2 gene transcription.
Transcription (transcription) of Tpl2 associated with inflammation and obesity
1) Confidence 0.52 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.66 Pain Relevance 0.09
This correlation strongly suggests that chronic inflammation may be involved in increased Tpl2 mRNA expression.
Transcription (expression) of Tpl2 associated with inflammation
2) Confidence 0.52 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.83 Pain Relevance 0.17
Interestingly, we found that Tpl2 mRNA expression was increased and was positively correlated with TNF-?
Transcription (expression) of Tpl2
3) Confidence 0.52 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.85 Pain Relevance 0.18
The increase in Tpl2 mRNA level was prevented by both IKK?
Transcription (level) of Tpl2
4) Confidence 0.52 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.60 Pain Relevance 0.15
Because Tpl2 mRNA expression was positively correlated with TNF-?
Transcription (expression) of Tpl2
5) Confidence 0.52 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.89 Pain Relevance 0.09
Moreover, Tpl2 mRNA expression was positively correlated with TNF-?
Transcription (expression) of Tpl2
6) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.80 Pain Relevance 0.03
treatment for 18 h increased Tpl2 mRNA level by 7.9- and 2.7-fold, respectively (Fig. 7B).
Transcription (level) of Tpl2
7) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.21 Pain Relevance 0.08
We then examined the expression of Tpl2 mRNA in subcutaneous adipose tissue of obese patients without or with type 2 diabetes and morbidly obese subjects (Table 1).
Spec (examined) Transcription (expression) of Tpl2 in subcutaneous adipose tissue associated with diabetes mellitus and obesity
8) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.99 Pain Relevance 0.08
We showed that Tpl2 mRNA expression is upregulated in adipose tissue of obese subjects and rodents and that inflammatory stimuli regulated Tpl2 expression.
Transcription (expression) of Tpl2 in adipose tissue associated with obesity and inflammatory stimuli
9) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.90 Pain Relevance 0.23
Tpl2 mRNA level is increased in adipose tissue of obese mice and subjects.
Transcription (level) of Tpl2 in adipose tissue associated with obesity
10) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.20 Pain Relevance 0.10
Tpl2 mRNA expression was increased in subcutaneous adipose tissue of obese subjects independently of diabetes and in adipose tissue of morbidly obese subjects compared with lean subjects (Fig. 6C).


Transcription (expression) of Tpl2 in subcutaneous adipose tissue associated with diabetes mellitus and obesity
11) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.97 Pain Relevance 0.09
Tpl2 mRNA expression was upregulated in adipose tissue of obese mice and patients and correlated with TNF-?
Transcription (expression) of Tpl2 in adipose tissue associated with obesity
12) Confidence 0.38 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797946 Disease Relevance 1.44 Pain Relevance 0.36
We showed that Tpl2 mRNA expression was increased in epididymal adipose tissue of ob/ob, db/db, and high-fat diet obese mice compared with their lean control littermates (Fig. 6A).
Transcription (expression) of Tpl2 in adipose tissue associated with obesity
13) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.64 Pain Relevance 0.06
In addition, a gene encoding the mitogen-activated protein kinase kinase kinase 8 was found linking the NF-kappaB, MAP kinase, and ERK kinase (Mek) pathways.
Transcription (found) of kinase 8
14) Confidence 0.34 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.14 Pain Relevance 0

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