INT226910

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) transport (Slc11a1) DNA binding (Nfkb1)
protein complex (Nfkb1) cytoplasm (Nfkb1) cytosol (Nfkb1)
Slc11a1 (Mus musculus)
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 44 86.16 High High
Eae 2 28.16 Quite Low
cytokine 22 5.00 Very Low Very Low Very Low
interstitial cystitis 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 52 97.04 Very High Very High Very High
INFLAMMATION 52 86.16 High High
Bladder Cancer 18 71.68 Quite High
Recurrence 4 47.44 Quite Low
Death 10 33.72 Quite Low
Overactive Bladder 36 26.44 Quite Low
Disease 6 24.76 Low Low
Injury 6 24.40 Low Low
Mycobacterial Infection 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because NF-kappaB played a central role in several gene networks here described, we predicted that BCG induces NF-kappaB translocation by using EMSA.
BCG Positive_regulation (induces) of Localization (translocation) of NF-kappaB
1) Confidence 0.11 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.07 Pain Relevance 0
Others have presented evidence that BCG activates nuclear translocation of the transcription factor NF-kappaB, since pretreatment of with sulfasalazine, an inhibitor of NF-kappaB activity, blocked the ability of BCG to induce IL-8 secretion [48,49].
BCG Positive_regulation (activates) of Localization (translocation) of NF-kappaB
2) Confidence 0.08 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.55 Pain Relevance 0.11

General Comments

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