INT226912

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.08

signal transduction (IL8) extracellular space (IL8) transport (Slc11a1) extracellular region (IL8) intracellular (IL8) plasma membrane (Slc11a1)

Slc11a1 (Mus musculus) IL8 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 22 79.12 cytokine 11 5.00 interstitial cystitis 3 5.00 Inflammatory response 2 5.00 Inflammatory stimuli 2 5.00 imagery 2 5.00 sodium channel 1 5.00 chemokine 1 5.00 Glutamate receptor 1 5.00 Eae 1 5.00

Disease Link Frequency Relevance Heat Cancer 26 90.00 Bladder Cancer 9 82.16 INFLAMMATION 26 79.12 Recurrence 2 57.92 Death 5 26.68 Overactive Bladder 18 5.00 Mycobacterial Infection 4 5.00 Apoptosis 4 5.00 Interstitial Cystitis 3 5.00 Injury 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Others have presented evidence that BCG activates nuclear translocation of the transcription factor NF-kappaB, since pretreatment of with sulfasalazine, an inhibitor of NF-kappaB activity, blocked the ability of BCG to induce IL-8 secretion [48,49].

BCG Positive_regulation (induce) of Localization (secretion) of IL-8

1) Confidence 0.05 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.58 Pain Relevance 0.08

General Comments

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