INT226985

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.37
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lias) molecular_function (Lias) cellular_component (Lias)
biological_process (Lias)
Anatomy Link Frequency
endothelial cells 1
brain 1
Lias (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 24 96.52 Very High Very High Very High
cerebral cortex 6 83.12 Quite High
Thalamus 9 81.76 Quite High
Hippocampus 15 78.88 Quite High
alcohol 3 61.64 Quite High
ketamine 3 53.12 Quite High
Inflammation 15 46.24 Quite Low
anesthesia 6 43.28 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 60 99.56 Very High Very High Very High
Obesity 45 58.08 Quite High
INFLAMMATION 18 46.24 Quite Low
Overdose 3 38.72 Quite Low
Injury 3 34.68 Quite Low
Wound Healing 12 5.00 Very Low Very Low Very Low
Weight Loss 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Ulcers 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We employed both immunohistochemistry and in situ hybridization to see whether LS injection leads to leptin overexpression in the brain.
Spec (whether) Gene_expression (injection) of LS in brain
1) Confidence 0.09 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.62 Pain Relevance 0.12
l of saline solution (n = 9), 0.8 M lactic acid solution (n = 7) or LS (n = 22) were injected using a 10 ?
Gene_expression (injected) of LS
2) Confidence 0.09 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.14 Pain Relevance 0.22
Because LS caused marked increase in leptin production in bovine endothelial cells and because leptin is involved in regulation of body weight we hypothesized that LS might also regulate leptin expression in the brain.
Gene_expression (expression) of LS in endothelial cells associated with body weight
3) Confidence 0.08 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.61 Pain Relevance 0.11

General Comments

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